Tetrahydro-2-(2-phenylethoxy)-2H-pyran

Base Information

• Chemical Name: Tetrahydro-2-(2-phenylethoxy)-2H-pyran
• CAS No.: 1927-61-3
• Molecular Formula: C13H18 O2
• Molecular Weight: 206.285
• Hs Code.: 2932999099
• European Community (EC) Number: 217-666-5
• DSSTox Substance ID: DTXSID80883772
• Nikkaji Number: J199.744K
• Mol file: 1927-61-3.mol

Synonyms:Tetrahydro-2-(2-phenylethoxy)-2H-pyran;1927-61-3;2-(2-PHENYLETHOXY)OXANE;2H-Pyran, tetrahydro-2-(2-phenylethoxy)-;EINECS 217-666-5;2-(2-phenylethoxy)tetrahydro-2h-pyran;SCHEMBL6879618;2-phenethoxytetrahydro-2h-pyran;DTXSID80883772;2-(Phenethyloxy)tetrahydro-2H-pyran

Chemical Property of Tetrahydro-2-(2-phenylethoxy)-2H-pyran

Chemical Property:

• Vapor Pressure: 0.00199mmHg at 25°C
• Boiling Point: 300.6°C at 760 mmHg
• Flash Point: 114.5°C
• PSA: 18.46000
• Density: 1.03g/cm³
• LogP: 2.77230
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 206.130679813
• Heavy Atom Count: 15
• Complexity: 164

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCOC(C1)OCCC2=CC=CC=C2

Technology Process of Tetrahydro-2-(2-phenylethoxy)-2H-pyran

There total 7 articles about Tetrahydro-2-(2-phenylethoxy)-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dihydro-2H-pyran (110-87-2) + 2-phenylethanol (60-12-8) → 2-(2-phenylethoxy)tetrahydro-2H-pyran (1927-61-3)

Guidance literature:

With H₆P₂W₁₈O₆₂; In toluene; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(02)01822-1

Reference yield: 89.0%

2-(prop-2-en-1-yloxy)oxane (69161-61-1,4203-49-0) + 2-phenylethanol (60-12-8) → 2-(2-phenylethoxy)tetrahydro-2H-pyran (1927-61-3)

Guidance literature:

With N-Bromosuccinimide; boron trifluoride diethyl etherate; In acetonitrile; at 20 ℃; for 20h;

DOI:10.1016/j.tetlet.2009.09.026

Reference yield: 89.0%

tetrahydro-2H-2-pyranol (694-54-2) + 2-phenylethanol (60-12-8) → 2-(2-phenylethoxy)tetrahydro-2H-pyran (1927-61-3)

Guidance literature:

With rhenium(VII) oxide; In dichloromethane; at 20 ℃; Time; Inert atmosphere;

DOI:10.3762/bjoc.9.174

upstream raw materials:

3,4-dihydro-2H-pyran

2-phenylethanol

TETRAHYDROPYRANE

2-(prop-2-en-1-yloxy)oxane

Downstream raw materials:

1-tert-butyldimethylsilyloxy-2-phenylethane

2-phenylethanol

5-Phenethyloxy-pentan-1-ol

2-Phenylethyl benzoate

Refernces

• 1、 Rajkumari, Kalyani,Laskar, Ikbal Bahar,Kumari, Anupama,Kalita, Bandita,Rokhum, Lalthazuala. "Highly selective tetrahydropyranylation/dehydropyranylation of alcohols and phenols using porous phenolsulfonic acid-formaldehyde resin catalyst under solvent-free condition". . . Retrieved 2020/02/18.
• 2、 Chehardoli, Gholamabbas,Ali Zolfigol, Mohammad,Derakhshanpanah, Fateme. "Direct Conversion of TMS-ethers to THP-ethers Catalyzed by {[K.18-Crown-6]Br3}n". . . Retrieved 2019/04/27.