3-[(E)-{[4-(morpholin-4-yl)phenyl]imino}methyl]phenol

Base Information

• Chemical Name: 3-[(E)-{[4-(morpholin-4-yl)phenyl]imino}methyl]phenol
• CAS No.: 7466-67-3
• Molecular Formula: C₁₇H₁₈N₂O₂
• Molecular Weight: 282.342
• Mol file: 7466-67-3.mol

Synonyms:NSC402734; NSC 409395

Chemical Property of 3-[(E)-{[4-(morpholin-4-yl)phenyl]imino}methyl]phenol

Chemical Property:

• Vapor Pressure: 2.92E-11mmHg at 25°C
• Boiling Point: 515.8°Cat760mmHg
• Flash Point: 265.8°C
• Density: 1.17g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[(E)-{[4-(morpholin-4-yl)phenyl]imino}methyl]phenol

There total 3 articles about 3-[(E)-{[4-(morpholin-4-yl)phenyl]imino}methyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-morpholino-4-yl-phenylamine (2524-67-6,86759-37-7) + meta-hydroxybenzaldehyde (100-83-4) → C17H18N2O2 (7466-67-3)

Guidance literature:

In methanol; at 100 ℃; for 3.5h; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.112162

Reference yield:

4-chlorobenzonitrile (100-00-5) → C17H18N2O2 (7466-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 19 h / 120 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 23 h / 20 °C

3: methanol / 3.5 h / 100 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; ethanol; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2020.112162

Reference yield:

1-morpholino-4-nitrobenzene (10389-51-2) → C17H18N2O2 (7466-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 23 h / 20 °C

2: methanol / 3.5 h / 100 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; In methanol; ethanol;

DOI:10.1016/j.ejmech.2020.112162

upstream raw materials:

4-morpholino-4-yl-phenylamine

meta-hydroxybenzaldehyde

4-chlorobenzonitrile

1-morpholino-4-nitrobenzene

Refernces