1-(2,6-dichlorophenyl)-N-methylmethanamine

Base Information

• Chemical Name: 1-(2,6-dichlorophenyl)-N-methylmethanamine
• CAS No.: 15205-19-3
• Molecular Formula: C8H9 Cl2 N
• Molecular Weight: 190.072
• Mol file: 15205-19-3.mol

Synonyms:Benzylamine,2,6-dichloro-N-methyl- (7CI,8CI); N-(2,6-Dichlorobenzyl)methylamine

Chemical Property of 1-(2,6-dichlorophenyl)-N-methylmethanamine

Chemical Property:

• Vapor Pressure: 0.0376mmHg at 25°C
• Boiling Point: 240.6°Cat760mmHg
• Flash Point: 99.3°C
• Density: 1.226g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,6-dichlorophenyl)-N-methylmethanamine

There total 4 articles about 1-(2,6-dichlorophenyl)-N-methylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,6-Dichlorobenzyl bromide (20443-98-5) + methylamine (74-89-5) → 1-(2,6-dichlorophenyl)-N-methylmethanamine (15205-19-3)

Guidance literature:

In ethanol; for 4h; Heating / reflux;

Reference yield:

(C6H3Cl2-2,6)CH=N-CH3 (75692-62-5) → 1-(2,6-dichlorophenyl)-N-methylmethanamine (15205-19-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h; Heating;

DOI:10.1021/jm00375a005

Reference yield:

2,6-dichlorobenzaldehyde (83-38-5) → 1-(2,6-dichlorophenyl)-N-methylmethanamine (15205-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / 80 °C

2: LiAlH₄ / diethyl ether / 2 h / Heating

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1021/jm00375a005

upstream raw materials:

(C₆H₃Cl₂-2,6)CH=N-CH₃

2,6-Dichlorobenzyl bromide

methylamine

2,6-dichlorobenzaldehyde

Downstream raw materials:

2-(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)-1H-isoindole-1,3(2H)-dione

2-(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)-1H-isoindole-1,3(2H)-dione

8-(benzyloxy)-5-{1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

N-(2,6-dichlorobenzyl)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-N,2,2,3,3-pentamethyl-4,14-dioxa-7-aza-3-silaheptadecan-17-amine

Refernces

• 1、 -. "TACHYKININ RECEPTOR ANTAGONISTS". Page 29. . Retrieved 2010/02/10.