Prostephanaberrine

Base Information

• Chemical Name: Prostephanaberrine
• CAS No.: 105608-27-3
• Molecular Formula: C₁₉H₂₁NO₅
• Molecular Weight: 343.379
• Mol file: 105608-27-3.mol

Synonyms:3a,10b-[2]Buteno-1H-[1,3]benzodioxolo[5,6-e]indole,hasubanan-8-one deriv.; (-)-Prostephanaberrine; Base B, from Stephaniajaponica; Prostephanaberrine

Chemical Property of Prostephanaberrine

Chemical Property:

• Vapor Pressure: 4.63E-12mmHg at 25°C
• Boiling Point: 530°Cat760mmHg
• Flash Point: 274.3°C
• PSA: 68.23000
• Density: 1.42g/cm³
• LogP: 1.60550

Purity/Quality:

Analysis control,HPLC≥95% ^*data from raw suppliers

Prostephanaberrine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Prostephanaberrine

There total 3 articles about Prostephanaberrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C19H23NO6 → (-)-prostephanaberrine (105608-27-3)

Guidance literature:

With sodium ethanolate; In ethanol; at 75 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/jo401889b

Reference yield:

(7β,8β,10β)-8,10-epoxy-7,8-dimethoxy-2,3-[methylenebis(oxy)]-17-methyl-6-oxohasubanan (1025023-05-5) → (-)-prostephanaberrine (105608-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 0.25 h / 0 °C / Inert atmosphere

2: hydrogenchloride / water / 4 h / 75 °C / Inert atmosphere

3: sodium ethanolate / ethanol / 0.33 h / 75 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; sodium ethanolate; In ethanol; water;

DOI:10.1021/jo401889b

Reference yield:

C20H23NO6 → (-)-prostephanaberrine (105608-27-3)

Guidance literature:

Multi-step reaction with 4 steps

1: formic acid / Inert atmosphere

2: sodium tetrahydroborate / ethanol / 0.25 h / 0 °C / Inert atmosphere

3: hydrogenchloride / water / 4 h / 75 °C / Inert atmosphere

4: sodium ethanolate / ethanol / 0.33 h / 75 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; formic acid; sodium ethanolate; In ethanol; water;

DOI:10.1021/jo401889b

upstream raw materials:

(7β,8β,10β)-8,10-epoxy-7,8-dimethoxy-2,3-[methylenebis(oxy)]-17-methyl-6-oxohasubanan

Downstream raw materials:

(-)-stephanaberrine

Refernces