(9S)-9-Amino-9-deoxoerythromycin

Base Information Edit

Chemical Name:(9S)-9-Amino-9-deoxoerythromycin
CAS No.:26116-56-3
Molecular Formula:C37H70N2O12
Molecular Weight:734.969
Hs Code.:
European Community (EC) Number:406-790-7
UNII:YX9KV1OMA4
DSSTox Substance ID:DTXSID00180750
Nikkaji Number:J79.364G
Wikidata:Q27144058
Metabolomics Workbench ID:66614
ChEMBL ID:CHEMBL290242
Mol file:26116-56-3.mol

Synonyms:9(s)-erythromycylamine;erythromyclamine;erythromyclamine, (9R)-isomer;erythromyclamine, (9S)-isomer

Suppliers and Price of (9S)-9-Amino-9-deoxoerythromycin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
(9S)-9-Amino-9-deoxoerythromycin
10mg
$ 1103.00

American Custom Chemicals Corporation
9(S)-ERYTHROMYCYLAMINE 95.00%
10MG
$ 1593.90

American Custom Chemicals Corporation
9(S)-ERYTHROMYCYLAMINE 95.00%
1MG
$ 704.55

Cayman Chemical
Erythromycylamine
10mg
$ 743.00

Cayman Chemical
Erythromycylamine
1mg
$ 99.00

Cayman Chemical
Erythromycylamine
5mg
$ 396.00

Medical Isotopes, Inc.
Erythromycylamine
1 mg
$ 860.00

TRC
Erythromycylamine
10mg
$ 1070.00

Usbiological
Erythromycylamine
1mg
$ 403.00

Usbiological
Erythromycylamine
1mg
$ 531.00

Total 32 raw suppliers

Chemical Property of (9S)-9-Amino-9-deoxoerythromycin Edit

Chemical Property:

Vapor Pressure:2.15E-30mmHg at 25°C
Melting Point:123-127°C
Refractive Index:1.539
Boiling Point:810.3 °C at 760 mmHg
PKA:13.41±0.70(Predicted)
Flash Point:443.8 °C
PSA：202.86000
Density:1.19 g/cm³
LogP:2.24410
Storage Temp.:-20°C Freezer
XLogP3:3.5
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:7
Exact Mass:734.49287567
Heavy Atom Count:51
Complexity:1140

Purity/Quality:

99.9% ^*data from raw suppliers

(9S)-9-Amino-9-deoxoerythromycin ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi,N
Hazard Codes:Xi,N
Statements: 41-50/53
Safety Statements: 26-39-60-61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1C(C(C(C(C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)N)C)O)(C)O
Isomeric SMILES:CC[C@@H]1[C@@]([C@@H]([C@H]([C@H]([C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)N)C)O)(C)O
Uses (9S)-9-Amino-9-deoxoerythromycin is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. (9S)-9-Amino-9-deoxoerythromycin is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine. Erythromycylamine is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. Erythromycylamine is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine. (9S)-9-Amino-9-deoxoerythromycin is a metabolite of Dirithromycin; an antibiotic

Technology Process of (9S)-9-Amino-9-deoxoerythromycin

There total 21 articles about (9S)-9-Amino-9-deoxoerythromycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.03%