2-(4-Aminopiperazin-1-yl)ethanol

Base Information

• Chemical Name: 2-(4-Aminopiperazin-1-yl)ethanol
• CAS No.: 3973-70-4
• Molecular Formula: C6H15N3O
• Molecular Weight: 145.205
• Hs Code.: 29335995
• European Community (EC) Number: 223-603-2
• NSC Number: 87954
• UNII: 8F9Y9H2BMJ
• DSSTox Substance ID: DTXSID60192814
• Nikkaji Number: J217.806K
• Wikidata: Q83065473
• Mol file: 3973-70-4.mol

Synonyms:1-Amino-4-(2-hydroxyethyl)piperazine;3973-70-4;2-(4-Aminopiperazin-1-yl)ethanol;1-Piperazineethanol, 4-amino-;4-Amino-1-piperazineethanol;8F9Y9H2BMJ;EINECS 223-603-2;NSC-87954;NSC87954;UNII-8F9Y9H2BMJ;SCHEMBL163306;DTXSID60192814;MFCD00006155;NSC 87954;2-(4-Amino-piperazin-1-yl)-ethanol;AKOS015897984;1-amino-4-(2-hydroxyethyl)-piperazine;BP-13178;BS-27974;CS-0204733;FT-0635089;1-Amino-4-(2-hydroxyethyl)piperazine, 96%

Chemical Property of 2-(4-Aminopiperazin-1-yl)ethanol

Chemical Property:

• Appearance/Colour: yellow crystalline powder and chunks
• Vapor Pressure: 0.000751mmHg at 25°C
• Melting Point: 105-107 °C(lit.)
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 273.1 °C at 760 mmHg
• Flash Point: 119 °C
• PSA: 52.73000
• Density: 1.106 g/cm³
• LogP: -0.95390
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 145.121512110
• Heavy Atom Count: 10
• Complexity: 91

Purity/Quality:

98%min ^*data from raw suppliers

1-Amino-4-(2-hydroxyethyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCN1CCO)N

Technology Process of 2-(4-Aminopiperazin-1-yl)ethanol

There total 1 articles about 2-(4-Aminopiperazin-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-amino-4-(2-hydroxyethyl)-piperazine (3973-70-4)

Guidance literature:

N¹-(β-Hydroxyethyl)-N⁴-nitroso-piperazin, Zn, Eg., Δ (60grad);

Reference yield: 91.0%

1-amino-4-(2-hydroxyethyl)-piperazine (3973-70-4) + 4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride (224789-26-8) → 2-[2-ethoxy-5-(4-(2-hydroxyethyl)-1-amino-piperazine-1-sulfonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Guidance literature:

Reference yield: 78.0%

1-amino-4-(2-hydroxyethyl)-piperazine (3973-70-4) + G'1 (169132-80-3) → C102H132N24O15P4S4

Guidance literature:

With 4 A molecular sieve; In chloroform; for 48h; Heating;

DOI:10.1021/jo960045b

Downstream raw materials:

2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid [4-(2-hydroxy-ethyl)-prperazin-1-yl]-amide

C₂₅H₂₈FN₉O

4-(9'-cyclopentyl-5'-methyl-6'-oxo-5',6',8',9'-tetrahydrospiro[cyclopropane-1,7'-pyrimido[4,5-b][1,4]diazepine]-2'-ylamino)-N-(4-(2-hydroxyethyl)piperazin-1-yl)-3-methoxybenzamide