(1R,2S)-2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol

Base Information

• Chemical Name: (1R,2S)-2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
• CAS No.: 390-28-3
• Molecular Formula: C11H17 N O3
• Molecular Weight: 211.261
• Hs Code.: 2922509090
• UNII: HUQ1KC1YLI
• NCI Thesaurus Code: C66119
• Mol file: 390-28-3.mol

Synonyms:Hydrochloride, Methoxamine;Methoxamedrin;Methoxamine;Methoxamine Hydrochloride;Metoxamine Wellcome;Vasoxin;Vasoxine;Vasoxyl;Vasylox;Wellcome, Metoxamine

Chemical Property of (1R,2S)-2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol

Chemical Property:

• Melting Point: 85-86 °C
• Boiling Point: 368.4°Cat760mmHg
• PKA: 11.87±0.45(Predicted)
• Flash Point: 176.6°C
• PSA: 64.71000
• Density: g/cm³
• LogP: 1.78470
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 211.12084340
• Heavy Atom Count: 15
• Complexity: 189

Purity/Quality:

99%, ^*data from raw suppliers

METHOXAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C1=C(C=CC(=C1)OC)OC)O)N
• Isomeric SMILES: C[C@@H]([C@@H](C1=C(C=CC(=C1)OC)OC)O)N
• Recent ClinicalTrials: Effect of 7 Days of Dosing With a 10 mg Rectal Suppository of NRL001in Patients With Faecal Incontinence
• Recent EU Clinical Trials: A multi-centre, phase II, double-blind, randomised, placebo-controlled, parallel group, dose-ranging study in patients with faecal incontinence; to evaluate the efficacy, safety and tolerability of locally applied NRL001 over an 8 week treatment period.
• Therapeutic Function: Hypertensive

Technology Process of (1R,2S)-2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol

There total 9 articles about (1R,2S)-2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ methoxamine (390-28-3)

Guidance literature:

α-Amino-2.5-dimethoxy-propiophenon, Al-Isopropylat, sd. Isopropylalkohol;

Reference yield:

2,5-dimethoxy-α-aminopropiophenone hydrochloride (103565-48-6) → 2-amino-1-(2,5-dimethoxyphenyl)-1-propanol (390-28-3,715-83-3,13641-73-1,13699-29-1,103553-77-1,121422-03-5,141977-82-4)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 25 ℃; for 48h;

DOI:10.1016/j.bmc.2004.05.033

Reference yield:

→ 2-amino-1-(2,5-dimethoxyphenyl)-1-propanol (390-28-3,715-83-3,13641-73-1,13699-29-1,103553-77-1,121422-03-5,141977-82-4)

Guidance literature:

With water; platinum; Hydrogenation;

DOI:10.1021/ja01264a501

upstream raw materials:

(1RS,2RS)-2-acetylamino-1-(2,5-dimethoxy-phenyl)-propan-1-ol

1-Acetoxy-1-(2,5-dimethoxy-phenyl)-2-nitro-propan

2,5-dimethoxy-α-aminopropiophenone hydrochloride

(RS)-2-trifluoroacetamido-1-(2,5-dimethoxyphenyl)-1-propanone

Downstream raw materials:

1-phenyl-2-(p-tolyl)ethylamine

2r-(2,5-dimethoxy-phenyl)-4-isopropyl-3c-methyl-morpholine

cis-2-(2,5-dimethoxy-phenyl)-3-methyl-morpholine

(1R,2S)-Methoxamine

Refernces

• 1、 Osorio-Olivares, Mauricio,Rezende, Marcos Caroli,Sepulveda-Boza, Silvia,Cassels, Bruce K.,Fierro, Angelica. "MAO inhibition by arylisopropylamines: The effect of oxygen substituents at the β-position". . p. 4055 - 4066. Retrieved 2007/10/03.