N-(4-Methoxy-2-methylphenyl)acetamide

Base Information

• Chemical Name: N-(4-Methoxy-2-methylphenyl)acetamide
• CAS No.: 31601-41-9
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 2924299090
• European Community (EC) Number: 250-724-8
• NSC Number: 16606
• UNII: Z44O1G96F6
• DSSTox Substance ID: DTXSID4067640
• Nikkaji Number: J29.472A
• Wikidata: Q81994266
• ChEMBL ID: CHEMBL1884770
• Mol file: 31601-41-9.mol

Synonyms:31601-41-9;2-ACETAMIDO-5-METHOXYTOLUENE;N-(4-Methoxy-2-methylphenyl)acetamide;Acetamide, N-(4-methoxy-2-methylphenyl)-;4-Acetamido-3-methylanisole;p-Acetanisidide, 2'-methyl-;3-Methyl-4-acetylaminoanisole;Z44O1G96F6;EINECS 250-724-8;MFCD00458126;NSC 16606;NSC-16606;N-(4-Methoxy-2-methylphenyl)-acetamide;N-[2-methyl-4-(methyloxy)phenyl]acetamide;N-(2-METHYL-4-(METHYLOXY)PHENYL)ACETAMIDE;4'-Methoxy-2'-methylacetanilide;NSC16606;N-(4-Methoxy-2-methyl-phenyl)-acetamide;MLS000710045;SCHEMBL678961;UNII-Z44O1G96F6;3-methoxy-6-acetylaminotoluene;CHEMBL1884770;DTXSID4067640;HMS2676B10;AKOS001044742;NCGC00245014-01;AS-31699;SMR000287212;SY003647;CS-0312854;FT-0740976;A875845;Z56871751

Chemical Property of N-(4-Methoxy-2-methylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 0.000111mmHg at 25°C
• Refractive Index: 1.552
• Boiling Point: 336.6 °C at 760 mmHg
• Flash Point: 157.3 °C
• PSA: 38.33000
• Density: 1.1 g/cm³
• LogP: 2.03500
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 182

Purity/Quality:

95% ^*data from raw suppliers

N-(4-Methoxy-2-methylphenyl)acetamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)OC)NC(=O)C

Technology Process of N-(4-Methoxy-2-methylphenyl)acetamide

There total 23 articles about N-(4-Methoxy-2-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetic anhydride (108-24-7) + 2-methyl-4-methoxyaniline (102-50-1) → N-(4-methoxy-2-methylphenyl)acetamide (31601-41-9)

Guidance literature:

With pyridine; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2011.11.010

Reference yield: 90.0%

2-methyl-4-methoxyaniline (102-50-1) + citric acid (77-92-9,906507-37-7) → N-(4-methoxy-2-methylphenyl)acetamide (31601-41-9)

Guidance literature:

With acetic anhydride; triethylamine; In dichloromethane;

Reference yield: 88.0%

2-methyl-4-methoxyaniline (102-50-1) → N-(4-methoxy-2-methylphenyl)acetamide (31601-41-9)

Guidance literature:

With acetic anhydride; In 2,4-dichlorophenoxyacetic acid dimethylamine;

upstream raw materials:

acetic anhydride

2-methyl-4-methoxyaniline

4-acetamido-3-methylphenol

dimethyl sulfate

Downstream raw materials:

2-(acetylamino)-5-methoxybenzoic acid

4-phenylamino-3-methyl-1-methoxybenzene

3-methoxy-6-(N-acetylanilino)-toluene

4,4-bis(4-methoxy-2-methylphenylamino)-p-terphenyl

Refernces

• 1、 Hu, Qingqing,Wang, Chao,Xiang, Qiuping,Wang, Rui,Zhang, Cheng,Zhang, Maofeng,Xue, Xiaoqian,Luo, Guolong,Liu, Xiaomin,Wu, Xishan,Zhang, Yan,Wu, Donghai,Xu, Yong. "Discovery and optimization of novel N-benzyl-3,6-dimethylbenzo[d]isoxazol-5-amine derivatives as potent and selective TRIM24 bromodomain inhibitors with potential anti-cancer activities". . . Retrieved 2019/12/26.
• 2、 Vodnala, Nagaraju,Gujjarappa, Raghuram,Hazra, Chinmoy K.,Kaldhi, Dhananjaya,Kabi, Arup. K.,Beifuss, Uwe,Malakar, Chandi C.. "Copper-Catalyzed Site-Selective Oxidative C?C Bond Cleavage of Simple Ketones for the Synthesis of Anilides and Paracetamol". supporting information. p. 135 - 145. Retrieved 2018/12/05.