Ionomycin calcium salt

Base Information

• Chemical Name: Ionomycin calcium salt
• CAS No.: 56092-82-1
• Molecular Formula: C41H72 O9 . Ca
• Molecular Weight: 747.08
• Hs Code.: 29419090
• DSSTox Substance ID: DTXSID101017257
• Wikipedia: Ionomycin
• ChEMBL ID: CHEMBL1222121
• Mol file: 56092-82-1.mol

Synonyms:Ionomycin calcium salt;56092-82-1;IONOMYCIN CALCIUM;Ionomycin, calcium salt;56092-82-1 (calcium);Ionomycin (calcium);C41H70O9.Ca;C41-H70-O9.Ca;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid calcium salt;calcium (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-((2S,2'R,5S,5'S)-5'-((R)-1-hydroxyethyl)-2,5'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate;Ionomycin calcium salt from Streptomyces conglobatus;SQ23377 calcium;10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, calcium salt (1:1), (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-;C41H70CaO9;CHEMBL1222121;DTXSID101017257;HB1001;HY-13434A;AKOS024456754;CS-0014217;Ionomycin calcium salt (1 mM solution in DMSO);Ionomycin calcium salt (1 mM solution in DMSO) is known as a selective calcium ionophore.;calcium;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate

Chemical Property of Ionomycin calcium salt

Chemical Property:

• Vapor Pressure: 6.15E-31mmHg at 25°C
• Melting Point: 205-206 C
• Boiling Point: 817.2°Cat760mmHg
• Flash Point: 235.2°C
• PSA: 131.75000
• Density: g/cm³
• LogP: 7.64540
• Storage Temp.: −20°C
• Sensitive.: Light Sensitive
• Solubility.: Soluble in DMSO (10mg/ml). Also soluble in ethanol or methanol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 21
• Exact Mass: 746.4645747
• Heavy Atom Count: 51
• Complexity: 1120

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ionomycin Calcium Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(CCC(=O)[O-])CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)[O-].[Ca+2]
• Isomeric SMILES: C[C@H](CCC(=O)[O-])C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\[O-].[Ca+2]
• Description: Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 μM. Ionomycin (5 μM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination with phorbol 12-myristate 13-acetate (PMA; ) has commonly been used to induce the proliferation and activation of T cells, as well as to stimulate cytokine production in macrophages, in vitro.
• Uses: Ionomycin is more effectivethan A23187 as a Ca++ionophore; Ionomycin is used in research on Ca++ transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neurons. Ionomycin calcium salt is used as a polyether antibiotic and apoptotic degeneration inducer. Ionomycin induces apoptotic degeneration of embryonic cortical neurons and cell cycle arrest at G1 phase. It is more effective than A23187 (sc-3591) and provides a useful tool for increasing intracellular Ca2+ concentration.