Morpholine-4-carboxamide

Base Information

• Chemical Name: Morpholine-4-carboxamide
• CAS No.: 2158-02-3
• Molecular Formula: C5H10 N2 O2
• Molecular Weight: 130.147
• Hs Code.: 2934999090
• European Community (EC) Number: 218-474-4
• NSC Number: 10542
• DSSTox Substance ID: DTXSID10175930
• Nikkaji Number: J299.124A
• Wikidata: Q83046270
• Mol file: 2158-02-3.mol

Synonyms:Morpholine-4-carboxamide;2158-02-3;4-Morpholinecarboxamide;morpholinamide;morpholineamide;morpholine amide;morpholino amide;SCHEMBL78979;DTXSID10175930;morpholine-4-carboxylic acid amide;NSC10542;EINECS 218-474-4;MFCD00085717;NSC 10542;NSC-10542;AKOS000137387;AS-47545;AI3-61349;CS-0144907;EN300-44832;VU0609701-1;F14225;A925120;AT-159/40222951;Z57474300;F3307-0044

Chemical Property of Morpholine-4-carboxamide

Chemical Property:

• Vapor Pressure: 0.019mmHg at 25°C
• Boiling Point: 252.7°Cat760mmHg
• Flash Point: 106.7°C
• PSA: 55.56000
• Density: 1.216g/cm³
• LogP: 0.03550
• Storage Temp.: 2-8°C
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 130.074227566
• Heavy Atom Count: 9
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

Morpholine-4-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)N

Technology Process of Morpholine-4-carboxamide

There total 17 articles about Morpholine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + trimethylsilyl isocyanate (1118-02-1) → morpholine-4-carboxylic acid amide (2158-02-3)

Guidance literature:

In isopropyl alcohol; at 20 ℃;

Reference yield: 97.0%

morpholine (110-91-8,99108-56-2) + urea (57-13-6) → morpholine-4-carboxylic acid amide (2158-02-3)

Guidance literature:

With iron(II) bromide; In 1,4-dioxane; at 150 ℃; for 6h; Inert atmosphere; Sealed tube;

DOI:10.1002/cssc.201600587

Reference yield: 94.0%

N-cyanomorpholine (1530-89-8) → morpholine-4-carboxylic acid amide (2158-02-3)

Guidance literature:

With [OsCl₂(η⁶-p-cymene)(PMe₂OH)]; water; at 40 ℃; for 0.5h; Reagent/catalyst; Inert atmosphere; Sealed tube;

DOI:10.1039/d0cy00523a

upstream raw materials:

morpholine

urea

(Z)-3-[(Morpholine-4-carbonyl)-amino]-2-phenyl-acrylic acid

(Z)-3-[(Morpholine-4-carbonyl)-amino]-2-phenyl-acrylic acid methyl ester

Downstream raw materials:

2,4-Dinitro-phenol; compound with morpholine-4-carboxylic acid amide

2,3,4,5,6-Pentachloro-phenol; compound with morpholine-4-carboxylic acid amide

morpholine picrate

Picric acid; compound with morpholine-4-carboxylic acid amide

Refernces

• 1、 Weisel et al.. "-". . p. 1055. Retrieved 1945.
• 2、 Basu, Priyanka,Dey, Tusar Kanto,Ghosh, Aniruddha,Biswas, Surajit,Khan, Aslam,Islam, Sk. Manirul. "An efficient one-pot synthesis of industrially valuable primary organic carbamates and: N -substituted ureas by a reusable Merrifield anchored iron(ii)-anthra catalyst [FeII(Anthra-Merf)] using urea as a sustainable carbonylation source". . p. 2630 - 2643. Retrieved 2020/02/20.
• 3、 Wu, Fan,Alom, Nur-E,Ariyarathna, Jeewani P.,Na?, Johannes,Li, Wei. "Regioselective Formal [3+2] Cycloadditions of Urea Substrates with Activated and Unactivated Olefins for Intermolecular Olefin Aminooxygenation". supporting information. p. 11676 - 11680. Retrieved 2019/07/31.