METHOXYMETHYL ISOTHIOCYANATE

Base Information

• Chemical Name: METHOXYMETHYL ISOTHIOCYANATE
• CAS No.: 19900-84-6
• Molecular Formula: C3H5NOS
• Molecular Weight: 103.145
• Mol file: 19900-84-6.mol

Synonyms:Isothiocyanatomethyl methyl ether;

Chemical Property of METHOXYMETHYL ISOTHIOCYANATE

Chemical Property:

• Vapor Pressure: 8.02mmHg at 25°C
• Refractive Index: 1.475
• Boiling Point: 139.4 °C at 760 mmHg
• Flash Point: 38.1 °C
• PSA: 53.68000
• Density: 1.03 g/cm³
• LogP: 0.69310
• Storage Temp.: Keep Cold

Purity/Quality:

98%min ^*data from raw suppliers

Methoxymethylisothiocyanate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHOXYMETHYL ISOTHIOCYANATE

There total 3 articles about METHOXYMETHYL ISOTHIOCYANATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

potassium thioacyanate (333-20-0) + chloromethyl methyl ether (107-30-2) → methoxymethyl isothiocyanate (19900-84-6)

Guidance literature:

In pentane; Heating;

DOI:10.1023/A:1020332313966 DOI:10.1023/B:RUJO.0000034923.10292.65

Reference yield:

potassium thioacyanate (333-20-0) + chloromethyl methyl ether (107-30-2) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → methoxymethyl isothiocyanate (19900-84-6)

Guidance literature:

at 110 ℃;

Reference yield:

→ methoxymethyl isothiocyanate (19900-84-6)

Guidance literature:

upstream raw materials:

potassium thioacyanate

chloromethyl methyl ether

benzene

Downstream raw materials:

N-methoxymethyl-N'-(2-vinylmercapto-phenyl)-thiourea

tri-O-benzoyl-1-(5-chloro-3-oxo-3H-[1,2,4]thiadiazol-2-yl)-β-D-1-deoxy-ribofuranose

3-(Methoxymethyl-thiocarbamoyl)-pyridine-2,6-dicarboxylic acid 6-amide 2-tert-butylamide

Refernces

• 1、 Nedolya, Nina A.,Tarasova, Olga A.,Albanov, Alexander I.,Trofimov, Boris A.. "Tert -Butoxide-Assisted Structural Transformation of 2-Aza-1,3,5-trienes: Fast Track to 5-Ethynyl-2-vinyl- and 2,5-Divinyl-1,3-thiazoles". . p. 4313 - 4324. Retrieved 2018.
• 2、 Nedolya,Brandsma,Shlyakhtina,Fedorov,Klyba. "Unconventional synthesis of pyridines with rare O- and S-functionality from lithiated allenes and isothiocyanates". . p. 917 - 918. Retrieved 2002.