Z-Gly-NH2

Base Information

• Chemical Name: Z-Gly-NH2
• CAS No.: 949-90-6
• Molecular Formula: C10H12N2O3
• Molecular Weight: 208.217
• European Community (EC) Number: 213-445-2
• NSC Number: 88477
• UNII: 6NLL3GNH3P
• DSSTox Substance ID: DTXSID90915230
• Nikkaji Number: J298.554C
• Wikidata: Q72441977
• ChEMBL ID: CHEMBL431275
• Mol file: 949-90-6.mol

Synonyms:Z-Gly-NH2;949-90-6;Z-glycine amide;Z-glycineamide;benzyl N-(2-amino-2-oxoethyl)carbamate;Benzyl carbamoylmethylcarbamate;benzyl (2-amino-2-oxoethyl)carbamate;N-(Benzyloxycarbonyl)glycinamide;Z-Gly-NH;6NLL3GNH3P;EINECS 213-445-2;MFCD00042825;NSC-88477;Z-glycinamide;N-Benzyloxycarbonylglycinamide;benzyloxycarbonylglycinamide;CBZ-Glyamide;benzyl N-(carbamoylmethyl)carbamate;CBZ-GLYCINAMIDE;UNII-6NLL3GNH3P;CARBOBENZOXYGLYCINAMIDE;Oprea1_197296;CHEMBL431275;SCHEMBL2820683;DTXSID90915230;2-(Benzyloxycarbonylamino)acetamide;benzyl 2-amino-2-oxoethylcarbamate;NSC88477;benzyl(2-amino-2-oxoethyl)carbamate;AB6158;NSC 88477;AKOS015913993;N-BENZYLOXYCARBONYLGLYCINE AMIDE;AM81792;CS-W015222;Carbamoylmethyl-carbamic acid benzyl ester;DS-13401;Z-Gly-NH2, >=99.0% (HPLC);FT-0622827;EN300-748995;J-300139;Q-101747;2-{[(Benzyloxy)(hydroxy)methylidene]amino}ethanimidic acid;Carbamic acid, (2-amino-2-oxoethyl)-, phenylmethyl ester;CARBAMIC ACID, N-(2-AMINO-2-OXOETHYL)-, PHENYLMETHYL ESTER

Chemical Property of Z-Gly-NH2

Chemical Property:

• Vapor Pressure: 3.46E-08mmHg at 25°C
• Melting Point: 136-139 °C
• Refractive Index: 1.554
• Boiling Point: 447.1 °C at 760 mmHg
• PKA: 11.80±0.46(Predicted)
• Flash Point: 224.2 °C
• PSA: 81.42000
• Density: 1.236 g/cm³
• LogP: 1.48930
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 208.08479225
• Heavy Atom Count: 15
• Complexity: 225

Purity/Quality:

98%,99%, ^*data from raw suppliers

Z-glycine amide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCC(=O)N

Technology Process of Z-Gly-NH2

There total 33 articles about Z-Gly-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl N-benzyloxycarbonylglycinate (1212-53-9) → N-(carbobenzyloxy)glycinamide (949-90-6)

Guidance literature:

With ammonium hydroxide;

DOI:10.1016/00404-0399(50)1347K-

Reference yield: 95.1%

Z-Gly-L-Azy-Gly-OBzl (72087-11-7) → N-(carbobenzyloxy)glycinamide (949-90-6) + (2S)-H-Azy-Gly-OBzl (76314-24-4)

Guidance literature:

With ammonia; In dichloromethane; for 1h; Product distribution; Ambient temperature; other amines, var. temperatures and reaction times;

DOI:10.1246/bcsj.53.283

Reference yield: 92.0%

N-(N-benzyloxycarbonyl-glycyl)-L-serine methyl ester (108849-83-8,10239-27-7) → N-(carbobenzyloxy)glycinamide (949-90-6)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; acetonitrile; for 8h; Ambient temperature; pH 3;

DOI:10.1021/ja00094a008

upstream raw materials:

phenylmethyl cyanomethylcarbamate

Sphenyl N-benzyloxycarbonylaminoethanothioate

ethyl 2-(benzyloxycarbonylamino)ethanoate

1,4-bis-chloroacetyl-piperazine-2,5-dione

Downstream raw materials:

(E/Z)-Z-Gly-Δ Ile

N-(N-benzyloxycarbonyl-L-leucyl)-glycine amide

Z-Gly-NH-Mbh

Benzyloxycarbonylglycin-isobutylamid

Refernces

• 1、 -. "UREA DERIVATIVES AS PYRUVATE KINASE ACTIVATORS". Paragraph 505-507. . Retrieved 2022/02/15.
• 2、 -. "SN38-containing antibody-drug conjugate". Paragraph 0119-0121. . Retrieved 2020/10/04.