3,5-diiodoaspirin

Base Information

• Chemical Name: 3,5-diiodoaspirin
• CAS No.: 36415-60-8
• Molecular Formula: C9H6 I2 O4
• Molecular Weight: 431.95
• Hs Code.: 2918990090
• Mol file: 36415-60-8.mol

Synonyms:Salicylicacid, 3,5-diiodo-, acetate (7CI); 2-O-Acetyl-3,5-diiodosalicylic acid;3,5-Diiodoacetylsalicylic acid

Chemical Property of 3,5-diiodoaspirin

Chemical Property:

• Vapor Pressure: 2.98E-09mmHg at 25°C
• Boiling Point: 459.9°Cat760mmHg
• PKA: 2.78±0.10(Predicted)
• Flash Point: 231.9°C
• PSA: 63.60000
• Density: 2.35g/cm³
• LogP: 2.51930

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-diiodoaspirin

There total 7 articles about 3,5-diiodoaspirin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-diiodosalicylic acid (133-91-5) + acetyl chloride (75-36-5) → 2-acetoxy-3,5-diiodo-benzoic acid (36415-60-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2008.04.068

Reference yield:

3,5-diiodosalicylic acid (133-91-5) + acetic anhydride (108-24-7) → 2-acetoxy-3,5-diiodo-benzoic acid (36415-60-8)

Guidance literature:

Reference yield:

5-Aminosalicylic Acid (89-57-6) → 2-acetoxy-3,5-diiodo-benzoic acid (36415-60-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Diazotization_.Eintragen der Diazoloesung in konzentrierte Jodwasserstoffsaeure und nachfolgendes Erwaermen auf 80-90grad

With sulfuric acid;

upstream raw materials:

3,5-diiodosalicylic acid

acetic anhydride

5-Aminosalicylic Acid

3-aminosalicylic acid

Downstream raw materials:

2-acetoxy-3,5-diiodo-benzoyl chloride

diethyl 2-{hydroxy[3,5-diiodo-2-(acetoxy)phenyl]methylene}malonate

Refernces

• 1、 Jung,Min,Park. "A highly practical route to 2-methylchromones from 2-acetoxybenzoic acids". . p. 1837 - 1845. Retrieved 2007/10/03.