3-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID

Base Information

• Chemical Name: 3-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID
• CAS No.: 19947-39-8
• Molecular Formula: > C9H10 Cl N O2
• Molecular Weight: 199.637
• Hs Code.: 29224999
• Mol file: 19947-39-8.mol

Synonyms:3-Amino-3-(4-chlorophenyl)propionicacid;NSC 400947;

Chemical Property of 3-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID

Chemical Property:

• Appearance/Colour: White crystals.
• Vapor Pressure: 2.29E-05mmHg at 25°C
• Melting Point: 223 °C (dec.)(lit.)
• Refractive Index: 1.588
• Boiling Point: 345.8 °C at 760 mmHg
• Flash Point: 162.9 °C
• PSA: 63.32000
• Density: 1.333 g/cm³
• LogP: 2.51480
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-3-(4-chlorophenyl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID

There total 4 articles about 3-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.3%

malonic acid (141-82-2) + 4-chlorobenzaldehyde (104-88-1) → 3-amino-3-(4-chlorophenyl)propionic acid (19947-39-8,131690-61-4)

Guidance literature:

With ammonium acetate; In ethanol; at 75 - 80 ℃; for 8h;

Reference yield: 65.0%

3-(4-Chloro-phenyl)-3-hydroxyamino-propionic acid (197785-39-0) → 3-amino-3-(4-chlorophenyl)propionic acid (19947-39-8,131690-61-4)

Guidance literature:

With sodium hydroxide; zinc; at 20 ℃; for 6h;

DOI:10.1071/C96216

Reference yield:

3-(4-chlorophenyl)prop-2-enoic acid (1615-02-7,940-62-5) → 3-amino-3-(4-chlorophenyl)propionic acid (19947-39-8,131690-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / NH₂OH*HCl, NaOEt / ethanol; H₂O / 18 h / Heating

2: 65 percent / Zn/2M NaOH / 6 h / 20 °C

With sodium hydroxide; hydroxylamine hydrochloride; sodium ethanolate; zinc; In ethanol; water;

DOI:10.1071/C96216

upstream raw materials:

malonic acid

4-chlorobenzaldehyde

3-(4-Chloro-phenyl)-3-hydroxyamino-propionic acid

3-(4-chlorophenyl)prop-2-enoic acid

Downstream raw materials:

3-[3N'-(2-chloroethyl)ureido]-3-(4-chlorophenyl)propionic acid

3-[N-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-3-(4-chloro)-phenylorpionic acid

3-(4-chlorophenyl)prop-2-enoic acid

p-chlorophenylalanine

Refernces

• 1、 Kashif, Muhammad,Chacón-Vargas, Karla Fabiola,López-Cedillo, Julio Cesar,Nogueda-Torres, Benjamín,Paz-González, Alma D.,Ramírez-Moreno, Esther,Agusti, Rosalia,Uhrig, Maria Laura,Reyes-Arellano, Alicia,Peralta-Cruz, Javier,Ashfaq, Muhammad,Rivera, Gildardo. "Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase". . p. 252 - 268. Retrieved 2018/07/14.
• 2、 Zhao, Dongmei,Sun, Bin,Ren, Jinhong,Li, Fengrong,Song, Shuai,Lv, Xuejiao,Hao, Chenzhou,Cheng, Maosheng. "Synthesis and biological evaluation of 3-phenyl-3-aryl carboxamido propanoic acid derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26A1)". . p. 1356 - 1365. Retrieved 2015/03/04.