2-O-Benzylglycolic acid ethyl ester

Base Information

• Chemical Name: 2-O-Benzylglycolic acid ethyl ester
• CAS No.: 32122-09-1
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Hs Code.: 2918990090
• Mol file: 32122-09-1.mol

Synonyms:Aceticacid, (benzyloxy)-, ethyl ester (6CI,8CI);Acetic acid, (phenylmethoxy)-, ethylester (9CI);Benzyloxy ethyl acetate;Benzyloxyacetic acid ethyl ester;Ethyl(benzyloxy)acetate;NSC 153412;Ethyl 2-(benzyloxy)acetate;

Chemical Property of 2-O-Benzylglycolic acid ethyl ester

Chemical Property:

• Vapor Pressure: 0.00294mmHg at 25°C
• Refractive Index: 1.497
• Boiling Point: 284.6 °C at 760 mmHg
• Flash Point: 98.7 °C
• PSA: 35.53000
• Density: 1.069 g/cm³
• LogP: 1.76630
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 2-(benzyloxy)acetate ^*data from reagent suppliers

Safty Information:

• Statements: 52

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-O-Benzylglycolic acid ethyl ester

There total 12 articles about 2-O-Benzylglycolic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

diazoacetic acid ethyl ester (623-73-4) + benzyl alcohol (100-51-6,185532-71-2) → ethyl benzyloxyacetate (32122-09-1)

Guidance literature:

With indium(III) chloride; at 20 ℃; for 1h; Neat (no solvent);

DOI:10.1016/j.tetlet.2011.04.099

Reference yield: 77.5%

ethyl bromoacetate (105-36-2) + benzyl alcohol (100-51-6,185532-71-2) → ethyl benzyloxyacetate (32122-09-1)

Guidance literature:

benzyl alcohol; With sodium hydride; In toluene; at 0 - 20 ℃; for 3.5h;

ethyl bromoacetate; In toluene; at 0 ℃; for 1.5h;

Reference yield: 73.0%

ethyl 2-hydroxyacetate (623-50-7) + benzyl bromide (100-39-0) → ethyl benzyloxyacetate (32122-09-1)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 12.5h; Inert atmosphere;

upstream raw materials:

diazoacetic acid ethyl ester

benzyl alcohol

benzyloxyacetonitrile

chloroacetic acid ethyl ester

Downstream raw materials:

2-benzyloxy-3-oxo-propionic acid ethyl ester

1-(benzyloxy)-2-methyl-2-propanol

Acetic acid (1R,2S)-2-((R)-4-benzyloxy-3-hydroxy-5-oxo-2,5-dihydro-furan-2-yl)-1-((2S,4R,5R)-5-ethyl-2,4-dimethyl-[1,3]dioxolan-4-yl)-propyl ester

2-Benzyloxy-4-methyl-3-oxopentansaeureethylester

Refernces

• 1、 Kurniawan, Yudhi D.,Tuck, Kellie L.,Castillón, Sergio,Robinson, Andrea J.. "Toward the stereoselective synthesis of zaragozic acid framework: A desilylation-aldol reaction approach". supporting information. . Retrieved 2021/11/08.
• 2、 Brenna, Stefano,Ardizzoia, G. Attilio. "Carbene Transfer and Carbene Insertion Reactions Catalyzed by a Mixed-Ligand Copper(I) Complex". . p. 3336 - 3342. Retrieved 2018/07/13.