N-Butylcyclohexylamine

Base Information

• Chemical Name: N-Butylcyclohexylamine
• CAS No.: 10108-56-2
• Molecular Formula: C10H21 N
• Molecular Weight: 155.283
• Hs Code.: 2921300090
• European Community (EC) Number: 233-294-6
• UNII: 8HI5X9ZR2A
• DSSTox Substance ID: DTXSID30905938
• Nikkaji Number: J23.470B
• Wikidata: Q27270518
• Mol file: 10108-56-2.mol

Synonyms:N-Butylcyclohexylamine;N-butylcyclohexanamine;Butylcyclohexylamine;Cyclohexanamine, N-butyl-;Cyclohexylamine, N-butyl-;10108-56-2;(Butylamino)cyclohexane;HSDB 2770;Cyclohexane, (butylamino)-;EINECS 233-294-6;N-BUTYL CYCLOHEXYLAMINE;N-n-butylcyclohexylamine;UNII-8HI5X9ZR2A;BRN 2346039;8HI5X9ZR2A;AI3-11527;4-12-00-00020 (Beilstein Handbook Reference);N-Butyl-N-(cyclohexyl)amine;Butylcyclohexylamin;n-Butyl-N-cyclohexylamine #;CYCLOHEXYL-N-BUTYLAMINE;SCHEMBL271797;DTXSID30905938;STL355868;AKOS000234978;N-BUTYL CYCLOHEXYLAMINE [HSDB];LS-57611;EN300-32369;Q27270518

Chemical Property of N-Butylcyclohexylamine

Chemical Property:

• Vapor Pressure: 0.204mmHg at 25°C
• Melting Point: 208.3°C
• Refractive Index: 1.4552 (estimate)
• Boiling Point: 209.3°Cat760mmHg
• Flash Point: 72.1°C
• PSA: 12.03000
• Density: 0.84g/cm³
• LogP: 3.09970
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 155.167399674
• Heavy Atom Count: 11
• Complexity: 84.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CCCCNC1CCCCC1

Technology Process of N-Butylcyclohexylamine

There total 39 articles about N-Butylcyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E,E)-N-Cyclohexyl-1-aza-1,3-pentadien (32820-47-6) → N-butylcyclohexylamine (10108-56-2)

Guidance literature:

With hydrogen; naphthalene; chromium tricarbonyl; In tetrahydrofuran; at 60 ℃; for 19h; under 51485.6 Torr;

DOI:10.1055/s-1993-25917

Reference yield: 97.0%

cyclohexylamine (108-91-8,157973-60-9) + butyraldehyde (123-72-8) → N-butylcyclohexylamine (10108-56-2)

Guidance literature:

With nickel; hydrogen; In neat (no solvent); at 200 ℃; under 760.051 Torr; Flow reactor;

DOI:10.1134/S1070363219120016

Reference yield: 96.0%

N-butylamine (109-73-9,85404-21-3) + phenol (108-95-2,27073-41-2) → N-butylcyclohexylamine (10108-56-2)

Guidance literature:

With palladium 10% on activated carbon; sodium formate; In water; at 60 ℃; for 0.333333h; Concentration; Temperature; Time; Microwave irradiation; Sealed tube;

DOI:10.1021/acs.orglett.5b01842

upstream raw materials:

N-cyclohexylbutylideneamine

N-(2-butenylidene)cyclohexylamine

N-ethylidenecyclohexylamine

N-cyclohexylidenebutylamine

Downstream raw materials:

6-[3-(N-Butyl-N-cyclohexylaminocarbonyl)-propoxy]carbostyril

N-cyclohexylbutylideneamine

α-(p-Chlorbenzyl)-phenylessigsaeure-N-butyl-N-cyclohexyl-amid

N-Isopropoxycarbonyl-3-(N-butyl-N-cyclohexylcarbamoyloxy)anilin

Refernces

• 1、 Sharma, Sumeet K.,Lynch, James,Sobolewska, Anna M.,Plucinski, Pawel,Watson, Robert J.,Williams, Jonathan M. J.. "Pt/C catalysed direct reductive amination of nitriles with primary amines in a continuous flow multichannel microreactor". . p. 85 - 88. Retrieved 2013.
• 2、 Yamashita, Masakazu,Kadokura, Mamoru,Suemitsu, Rikisaku. "The Reductive Amination of Carbonyl Compounds Using Sodium Hydrogentelluride as a Reducing Reagent". . p. 3359 - 3360. Retrieved 1984.
• 3、 Botta, Maurizio,Angelis, Francesco De,Gambacorta, Augusto,Labbiento, Lucia,Nicoletti, Rosario. "Reduction of Schiff Bases with Isopropyl Alcohol and Aluminum Isopropoxide in the Presence of Raney Nickel". . p. 1916 - 1919. Retrieved 1985.
• 4、 Saxena, Ira,Borah, Ruli,Sarma, Jadab C.. "Reductive amination of aromatic aldehydes and ketones with nickel boride". . p. 503 - 504. Retrieved 2000.
• 5、 Louka, Anastasia,Kidonakis, Marios,Saridakis, Iakovos,Zantioti-Chatzouda, Elisavet-Maria,Stratakis, Manolis. "Diethylsilane as a Powerful Reagent in Au Nanoparticle-Catalyzed Reductive Transformations". . p. 3508 - 3514. Retrieved 2020/06/02.
• 6、 Mokhov, V. M.,Nebykov, D. N.,Paputina, A. N.,Popov, Yu. V.,Shishkin, E. V.. "Colloidal and Nanosized Catalysts in Organic Synthesis: XXIII. Reductive Amination of Carbonyl Compounds Catalyzed by Nickel Nanoparticles in a Plug-Flow Reactor". . p. 2333 - 2340. Retrieved 2020/02/25.