3'-(TRIFLUOROMETHYL)PROPIOPHENONE

Base Information

• Chemical Name: 3'-(TRIFLUOROMETHYL)PROPIOPHENONE
• CAS No.: 1533-03-5
• Molecular Formula: C10H9F3O
• Molecular Weight: 202.176
• Hs Code.: 29147000
• Mol file: 1533-03-5.mol

Synonyms:Propiophenone,3'-(trifluoromethyl)- (7CI,8CI);1-[3-(Trifluoromethyl)phenyl]propan-1-one;Ethyl 3-(trifluoromethyl)phenyl ketone;1-[3-(Trifluoromethyl)phenyl]propanone;m-Trifluoromethylpropiophenone;Propiophenone, 3'-(trifluoromethyl);

Chemical Property of 3'-(TRIFLUOROMETHYL)PROPIOPHENONE

Chemical Property:

• Appearance/Colour: colorless transparent liquid or solid
• Vapor Pressure: 0.405mmHg at 25°C
• Melting Point: 18 °C
• Refractive Index: n20/D 1.4620(lit.)
• Boiling Point: 201.7 °C at 760 mmHg
• Flash Point: 91.1 °C
• PSA: 17.07000
• Density: 1.182 g/cm³
• LogP: 3.29810
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3''-(Trifluoromethyl)propiophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-(TRIFLUOROMETHYL)PROPIOPHENONE

There total 8 articles about 3'-(TRIFLUOROMETHYL)PROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-<3-(trifluoromethyl)phenyl>propan-1-ol (618-97-3,575433-48-6) → 3-(trifluoromethyl)propiophenone (1533-03-5)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In acetone; for 2h;

DOI:10.1016/0223-5234(96)88213-4

Reference yield:

α,α,α-trifluorotoluene (98-08-8) + propionyl chloride (79-03-8) → 3-(trifluoromethyl)propiophenone (1533-03-5)

Guidance literature:

propionyl chloride; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 0 ℃; for 0.166667h;

α,α,α-trifluorotoluene; In 1,2-dichloro-ethane; at 0 - 50 ℃;

DOI:10.1039/c5ob01929j

Reference yield:

3-trifluoromethylaniline (98-16-8) → 3-(trifluoromethyl)propiophenone (1533-03-5)

Guidance literature:

upstream raw materials:

1-<3-(trifluoromethyl)phenyl>propan-1-ol

Diazoethan

3-Trifluoromethylbenzaldehyde

3-trifluoromethylbenzonitrile

Downstream raw materials:

m-Trifluormethyl-propiophenon-semicarbazon

2-(camphorsulfonyl)-m-(trifluoromethyl)propiophenone

(R)-1-(3-(trifluoromethyl)phenyl)-1-oxopropan-2-yl 4-methylbenzenesulfonate

Refernces

• 1、 Martínez-Montero, Lía,Gotor, Vicente,Gotor-Fernández, Vicente,Lavandera, Iván. "Stereoselective amination of racemic sec-alcohols through sequential application of laccases and transaminases". supporting information. p. 474 - 480. Retrieved 2017/06/23.
• 2、 Siddaraju, Yogesh,Prabhu, Kandikere Ramaiah. "A chemoselective α-aminoxylation of aryl ketones: a cross dehydrogenative coupling reaction catalysed by Bu4NI". supporting information. p. 11651 - 11656. Retrieved 2015/12/08.