1-benzyltriazole

Base Information

• Chemical Name: 1-benzyltriazole
• CAS No.: 4368-68-7
• Molecular Formula: C9H9 N3
• Molecular Weight: 159.191
• Mol file: 4368-68-7.mol

Synonyms:1H-1,2,3-Triazole,1-benzyl- (7CI,8CI); 1-Benzyl-1H-1,2,3-triazole; N-Benzyl-1H-1,2,3-triazole;NSC 222409

Chemical Property of 1-benzyltriazole

Chemical Property:

• Vapor Pressure: 0.000607mmHg at 25°C
• Melting Point: 61 °C
• Boiling Point: 310.3°Cat760mmHg
• PKA: 1.18±0.10(Predicted)
• Flash Point: 141.4°C
• PSA: 30.71000
• Density: 1.13g/cm³
• LogP: 1.32640
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%min ^*data from raw suppliers

1-Benzyl-1H-1,2,3-triazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyltriazole

There total 40 articles about 1-benzyltriazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

vinyl acetate (108-05-4,9003-20-7) + benzyl azide (622-79-7) → 1-benzyl-1H-[1,2,3]triazole (4368-68-7)

Guidance literature:

With trimethyl orthoformate; at 120 ℃; for 30h;

DOI:10.1021/ja0319238

Reference yield: 99.0%

benzyl azide (622-79-7) + acetylene (74-86-2,25067-58-7) → 1-benzyl-1H-[1,2,3]triazole (4368-68-7)

Guidance literature:

With bis[1-(4-potassiumsulfonatebutyl)-3-(2,4,6-trimethylphenyl)-4,5-dihydroimidazolyl-3-ylidine]copper(I) hexafluorophosphate; In water; at 20 ℃; for 18h;

DOI:10.1039/c4ob01350f

Reference yield: 97.0%

difluoroacetaldehyde N-tosylhydrazone + benzylamine (100-46-9) → 1-benzyl-1H-[1,2,3]triazole (4368-68-7)

Guidance literature:

With sodium hydride; In ethyl acetate; at 40 ℃;

DOI:10.1016/j.cclet.2021.09.008

upstream raw materials:

1-benzyl-1H-[1,2,3]-triazole-4,5-dicarboxylic acid

benzyl azide

acetylene

1,2,3-triazole

Downstream raw materials:

1-benzyl-5-phenyl-1H-1,2,3-triazole

1-benzyl-5-(4-methylphenyl)-1H-1,2,3-triazole

1-benzyl-4,5-di-p-tolyl-1H-1,2,3-triazole

1-benzyl-5-(thiophen-2-yl)-1H-1,2,3-triazole

Refernces

• 1、 Keshavarz, Mosadegh,Taib, Layla A.. "A fascinating click strategy to novel 1,2,3-triazolium based organic-inorganic hybrids for highly accelerated preparation of tetrazolopyrimidines". . . Retrieved 2022/01/03.
• 2、 Fico, Dominic,Gorden, John D.,Johnson, Shanina S.,King, Lauren B.,Lin, Zi Jie,Martz, Luke,Rodriguez, Isabelle,Shelton, Kerri L.,Ta, Thong,Wilson, Julie A.. "Synthesis, characterization, and antimicrobial activity of lipophilic N,N′-bis-substituted triazolium salts". supporting information. . Retrieved 2021/11/30.