Glycyl-L-aspartic acid

Base Information

• Chemical Name: Glycyl-L-aspartic acid
• CAS No.: 4685-12-5
• Molecular Formula: C6H10N2O5
• Molecular Weight: 190.156
• Hs Code.: 2924199090
• European Community (EC) Number: 225-140-1
• Nikkaji Number: J149.619K
• Wikidata: Q27144120
• Metabolomics Workbench ID: 78799
• ChEMBL ID: CHEMBL91392
• Mol file: 4685-12-5.mol

Synonyms:bis(glycyl-L-aspartic acid) oxalate 0.4-hydrate;glycyl-L-aspartic acid;glycylaspartic acid;glycylaspartic acid, (DL)-isomer;N-glycyl-L-aspartic acid

Chemical Property of Glycyl-L-aspartic acid

Chemical Property:

• Vapor Pressure: 4.41E-10mmHg at 25°C
• Melting Point: ~205 °C
• Refractive Index: 13 ° (C=2, H2O)
• Boiling Point: 468.7 °C at 760 mmHg
• Flash Point: 237.3 °C
• PSA: 129.72000
• Density: 1.499 g/cm³
• LogP: -0.91960
• Storage Temp.: -15°C
• Water Solubility.: almost transparency in Water
• XLogP3: -4.5
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 190.05897142
• Heavy Atom Count: 13
• Complexity: 227

Purity/Quality:

98%,99%, ^*data from raw suppliers

Glycyl-L-asparticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: C(C(C(=O)O)NC(=O)CN)C(=O)O
• Isomeric SMILES: C([C@@H](C(=O)O)NC(=O)CN)C(=O)O
• Uses: Glycyl-L-aspartic Acid is a reagent used in the preparation of environmentally benign CO2-based copolymers.

Technology Process of Glycyl-L-aspartic acid

There total 6 articles about Glycyl-L-aspartic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-chloroacetyl-L-aspartic acid (67036-33-3) → glycyl-L-aspartic acid ammonium salt + glycyl-L-aspartic acid (4685-12-5)

Guidance literature:

Reference yield:

Z-Gly-Asp(OBu)-OH (131668-52-5) → glycyl-L-aspartic acid (4685-12-5)

Guidance literature:

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In N,N-dimethyl-formamide; for 48h; Title compound not separated from byproducts;

DOI:10.1007/BF02464250

Reference yield:

N-chloroacetyl-L-aspartic acid (67036-33-3) → glycyl-L-aspartic acid (4685-12-5)

Guidance literature:

With ammonia;

upstream raw materials:

N-chloroacetyl-L-aspartic acid

Z-Gly-Asp(OBzl)-OBzl

L-Aspartic acid dimethyl ester

N-(Benzyloxycarbonyl)glycine

Downstream raw materials:

Arg-Gly-Asp

methyl 2-(3,6-dioxopiperazin-2-yl)acetate

cyclo(Asp-Gly)

L-Aspartic acid

Refernces

• 1、 -. "Cyclic anticoagulant peptides". . . Retrieved 2008/06/13.
• 2、 -. "Anticoagulant peptide alcohols". . . Retrieved 2008/06/13.