Fluorescein dibutyrate

Base Information

• Chemical Name: Fluorescein dibutyrate
• CAS No.: 7298-65-9
• Molecular Formula: C28H24O7
• Molecular Weight: 472.494
• Hs Code.: 29329990
• NSC Number: 83608
• UNII: ONT4U528WD
• DSSTox Substance ID: DTXSID6064618
• Nikkaji Number: J421.849C
• Wikidata: Q81991703
• Mol file: 7298-65-9.mol

Synonyms:Fluorescein dibutyrate;7298-65-9;Fluorescein, dibutyrate;(6'-butanoyloxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) butanoate;ONT4U528WD;NSC 83608;NSC-83608;Butanoic acid, 3-oxospiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3',6'-diyl ester;Butanoic acid, 3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl ester;C28H24O7;3-Oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl dibutyrate;Butanoic acid, 1,1'-(3-oxospiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3',6'-diyl) ester;FERRICARSENIDE;FLUORESCEINDIBUTYRATE;UNII-ONT4U528WD;SCHEMBL2286694;DTXSID6064618;NSC83608;MFCD00037842;AKOS015888869;AS-57856;CS-0010016;FT-0770307;D96072;Butanoic acid,9'-[9H]xanthene]-3',6'-diyl ester;J-100163;3-Oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyldibutyrate;6'-(butanoyloxy)-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-3'-yl butanoate

Chemical Property of Fluorescein dibutyrate

Chemical Property:

• Vapor Pressure: 5.35E-16mmHg at 25°C
• Melting Point: 118-119 °C(lit.)
• Refractive Index: 1.642
• Boiling Point: 634.4°C at 760 mmHg
• Flash Point: 271.6°C
• PSA: 88.13000
• Density: 1.35g/cm³
• LogP: 5.66560
• Storage Temp.: 2-8°C
• Solubility.: DMF: soluble
• XLogP3: 5.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 472.15220310
• Heavy Atom Count: 35
• Complexity: 765

Purity/Quality:

99%, ^*data from raw suppliers

FluoresceinDibutyrate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(=O)OC1=CC2=C(C=C1)C3(C4=C(O2)C=C(C=C4)OC(=O)CCC)C5=CC=CC=C5C(=O)O3
• Uses: Fluorogenic substrate for esterase and lipase. Fluorescein dibutyrate is a fluorogenic substrate for esterase and lipase.

Technology Process of Fluorescein dibutyrate

There total 2 articles about Fluorescein dibutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

butyryl chloride (141-75-3) + fluorescein (2321-07-5,126605-73-0) → fluorescein diabutyrate (7298-65-9)

Guidance literature:

With dmap; triethylamine; In toluene; for 24h; Inert atmosphere;

DOI:10.1039/c4ob00247d

Reference yield:

→ fluorescein diabutyrate (7298-65-9)

Guidance literature:

Fluorescein, Buttersaeureanhydrid, Py.;

DOI:10.1021/ac60197a027

Reference yield:

fluorescein diabutyrate (7298-65-9)

Guidance literature:

Geschw.der enzymatischen Hydrolyse;

DOI:10.1021/ac60197a027

upstream raw materials:

butyryl chloride

fluorescein

Refernces

• 1、 Poznik,Koenig. "Cooperative hydrolysis of aryl esters on functionalized membrane surfaces and in micellar solutions". supporting information. p. 3175 - 3180. Retrieved 2014/05/06.