Thioguanine 9betaD-5'-deoxyriboside

Base Information

• Chemical Name: Thioguanine 9betaD-5'-deoxyriboside
• CAS No.: 4680-63-1
• Molecular Formula: C10H13N5O3S
• Molecular Weight: 283.311
• NSC Number: 403581
• DSSTox Substance ID: DTXSID80391261
• Mol file: 4680-63-1.mol

Synonyms:Thioguanine 9.beta.D-5'-deoxyriboside;4680-63-1;DTXSID80391261;NSC403581;NSC-403581;Thioguanine 5'-deoxy-.beta.-D-riboside

Chemical Property of Thioguanine 9betaD-5'-deoxyriboside

Chemical Property:

• Vapor Pressure: 3.11E-19mmHg at 25°C
• Boiling Point: 676.6°C at 760 mmHg
• Flash Point: 363°C
• Density: 2.04g/cm³
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 283.07391047
• Heavy Atom Count: 19
• Complexity: 433

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C(C(C(O1)N2C=NC3=C2NC(=NC3=S)N)O)O

Technology Process of Thioguanine 9betaD-5'-deoxyriboside

There total 2 articles about Thioguanine 9betaD-5'-deoxyriboside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thioguanine (154-42-7) + 5'-deoxyadenosine (4754-39-6) → 2-amino-9-(5-deoxy-β-D-ribofuranosyl)-9H-6-thiopurine (4680-63-1)

Guidance literature:

With nucleoside phosphorylase; sodium phosphate; adenosine deaminase; Yield given. Multistep reaction; 1.) water, pH 7.4, room temperature, 20 h, 2.) water, 37 deg C, 7 days;

DOI:10.1016/S0040-4020(98)00476-1

Reference yield:

→ 2-Amino-9-(5'-deoxy-D-ribofuranosyl)-9H-purinthiol-(6) (4680-63-1)

Guidance literature:

2',3'-Diacetat (Rohprodukt), sied.W.; Ausbeute 32percent;

DOI:10.1021/jo01064a061

upstream raw materials:

thioguanine

5'-deoxyadenosine

Refernces

• 1、 Reist et al.. "-". . p. 1557. Retrieved 1961.