Icariside F2

Base Information

• Chemical Name: Icariside F2
• CAS No.: 115009-57-9
• Molecular Formula: C18H26 O10
• Molecular Weight: 402.398
• Mol file: 115009-57-9.mol

Synonyms:Benzylalcohol 7-O-b-D-apiofuranosyl-(1®6)-b-D-glucopyranoside; Benzyl alcohol O-b-D-apiofuranosyl-(1®6)-b-D-glucopyranoside; Icariside F2

Chemical Property of Icariside F2

Chemical Property:

• PSA: 158.30000
• LogP: -2.53200
• Storage Temp.: ?20°C

Purity/Quality:

99%+, ^*data from raw suppliers

Icariside F2 ≥90% (LC/MS-ELSD) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Icariside F2

There total 9 articles about Icariside F2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl 2,3,4-tri-O-acetyl-6-O-<(3-C-acetoxymethyl)-2,3-di-O-acetyl-β-D-erythrofuranosyl>-β-D-glucopyranoside → icariside F2 (115009-57-9)

Guidance literature:

With sodium methylate; In methanol; for 1h; Ambient temperature;

DOI:10.1016/0008-6215(94)80057-X

Reference yield: 23.0%

benzyl 6-O-(2,3-O-isopropylidene-β-D-apiofuranosyl)-β-D-glucopyranoside → icariside F2 (115009-57-9)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 0.166667h;

Reference yield:

2,3,4-tri-O-acetyl-6-O-<(3-C-acetoxymethyl)-2,3-di-O-acetyl-β-D-erythrofuranosyl>-α-D-glucopyranosyl trichloroacetimidate → icariside F2 (115009-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / BF₃*Et₂O / CH₂Cl₂ / Ambient temperature

2: 100 percent / MeONa / methanol / 1 h / Ambient temperature

With boron trifluoride diethyl etherate; sodium methylate; In methanol; dichloromethane;

DOI:10.1016/0008-6215(94)80057-X

upstream raw materials:

(3-C-acetoxymethyl)-1,2,3-tri-O-acetyl-β-D-erythrofuranose

Acetic acid (3aS,6aR)-6-acetoxy-2,2-dimethyl-dihydro-furo[3,4-d][1,3]dioxol-3a-ylmethyl ester

Downstream raw materials:

D-apiose

Refernces

• 1、 Suzuki, Yoshihito,Yamaguchi, Isomaro,Murofushi, Noboru,Takahashi, Nobutaka,Sugawara, Fumio,et al.. "Synthesis of Benzyl 6-O-β-D-apiofurnosyl-β-D-glucopyranoside, a Metabolite of Benzoic Acid in Lemna paucicostata". . p. 1261 - 1266. Retrieved 2007/10/02.