ACONINE

Base Information

• Chemical Name: ACONINE
• CAS No.: 509-20-6
• Molecular Formula: C25H41 N O9
• Molecular Weight: 499.602
• Mol file: 509-20-6.mol

Synonyms:Aconine(6CI,7CI); 11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine,aconitane-3,8,13,14,15-pentol deriv.; Jesaconine

Chemical Property of ACONINE

Chemical Property:

• Vapor Pressure: 2.67E-18mmHg at 25°C
• Melting Point: 129-131ºC
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 626.1°Cat760mmHg
• PKA: 9.52(at 25℃)
• Flash Point: 332.4°C
• PSA: 141.31000
• Density: 1.42g/cm³
• LogP: -1.84950
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), DMSO (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Aconine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Aconine is an alkaloid originally isolated from Aconitum species and active metabolite of aconitine. It inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay in a concentration-dependent manner. Aconine also inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells. Aconine is an alkaloid originally isolated from Aconitum species and active metabolite of aconitine. It inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay in a concentration-dependent manner. Aconine also inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells. In vivo, aconine is toxic to mice when administered intravenously at a dose of 120 mg/kg. It induces flaccid paralysis and toxicity in rats with toxic dose (TD50) and LD50 values of 1.5 and 1.7 μmol per animal, respectively.
• Uses: Aconine is a derivative of Aconitine (A189875), a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.

Technology Process of ACONINE

There total 5 articles about ACONINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acotinine (302-27-2) → Aconine (509-20-6)

Guidance literature:

With water; at 170 ℃;

DOI:10.1002/ardp.19062440123

Reference yield:

→ Aconine (509-20-6)

Guidance literature:

With water; at 170 ℃;

Reference yield:

aconitine (302-27-2,140188-61-0) → aconine (509-20-6) + benzoylaconine

Guidance literature:

With water; for 8h; Heating;

DOI:10.1002/hlca.19840670740

upstream raw materials:

acotinine

aconitine

Downstream raw materials:

Mesaconine

Refernces

• 1、 Suginome et al.. "-". . p. 819,823. Retrieved 1959.