2,4,5-Triamino-6-hydroxypyrimidine sulfate

Base Information

• Chemical Name: 2,4,5-Triamino-6-hydroxypyrimidine sulfate
• CAS No.: 35011-47-3
• Molecular Formula: C4H7N5O^.H2SO4
• Molecular Weight: 239.212
• Hs Code.: 29349990
• Mol file: 35011-47-3.mol

Synonyms:2,5,6-Triamino-4-pyrimidol sulfate;6-Hydroxy-2,4,5-triaminopyrimidine sulfatehydrate;4 (1H)-Pyrimidinone, 2,5, 6-triamino-, sulfate (1:1);

Chemical Property of 2,4,5-Triamino-6-hydroxypyrimidine sulfate

Chemical Property:

• Appearance/Colour: yellow-beige crystalline powder
• Melting Point: ≥300 °C(lit.)
• Refractive Index: 1.772
• Boiling Point: 277 °C at 760 mmHg
• Flash Point: 121.3 °C
• PSA: 206.79000
• Density: 2.033g/cm3
• LogP: 0.68810
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Soluble in DMSO.

Purity/Quality:

99% ^*data from raw suppliers

6-Hydroxy-2,4,5-triaminopyrimidine,Sulfate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2,4,5-Triamino-6-hydroxypyrimidine sulfate is used in the preparation of guanines and other purine derivatives with antiviral activities. 2,4,5-Triamino-6-hydroxypyrimidine Sulfate Salt is an intermediate used in the preparation of labelled 2-Amino-6,8-dihydroxypurine Hydrochloride (A604920). A labelled substituted 5-aminopyrimidines with antioxidative activity.

Technology Process of 2,4,5-Triamino-6-hydroxypyrimidine sulfate

There total 2 articles about 2,4,5-Triamino-6-hydroxypyrimidine sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,4-diamino6-hydroxy-5-nitroso pyrimidine (2387-48-6) → 2,4,5-triamino-6-hydroxypyrimidine sulfate (35011-47-3)

Guidance literature:

With 5%-palladium/activated carbon; sodium hydroxide; In water; at 60 ℃; for 5h; under 7500.75 Torr; Inert atmosphere; Autoclave;

Reference yield:

C4H5N5O2 → 2,4,5-triamino-6-hydroxypyrimidine sulfate (35011-47-3)

Guidance literature:

C₄H₅N₅O₂; With hydrogenchloride; iron; In water;

With sulfuric acid;

Reference yield: 94.3%

2,4,5-triamino-6-hydroxypyrimidine sulfate (35011-47-3) + formamide (77287-34-4,77287-35-5,60100-09-6) → 2-amino-1,9-dihydro-6H-purin-6-one (73-40-5)

Guidance literature:

With formic acid; for 11h; Time; Concentration; Reflux;

upstream raw materials:

2,4-diamino6-hydroxy-5-nitroso pyrimidine

Downstream raw materials:

4-((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methylamino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide

2-amino-6,8-bis-(4-butyl-phenyl)-7,7-dioxo-3,6,7,8-tetrahydro-7λ⁶-thieno[3,4-g]pteridin-4-one

2-amino-6,8-bis-(4-chloro-phenyl)-7,7-dioxo-3,6,7,8-tetrahydro-7λ⁶-thieno[3,4-g]pteridin-4-one

2-amino-6,8-bis-(3,4-dimethyl-phenyl)-7,7-dioxo-3,6,7,8-tetrahydro-7λ⁶-thieno[3,4-g]pteridin-4-one

Refernces

• 1、 -. "IKK-β as target to 2-acetyl-8-substituted guanine derivatives, application and its preparation method (by machine translation)". Paragraph 0018. . Retrieved 2017/03/28.