Hexadecanamide

Base Information

• Chemical Name: Hexadecanamide
• CAS No.: 629-54-9
• Deprecated CAS: 83381-70-8
• Molecular Formula: C16H33 N O
• Molecular Weight: 255.444
• Hs Code.: 2924297099
• European Community (EC) Number: 211-095-5
• NSC Number: 3327
• UNII: QX1MQ82M73
• DSSTox Substance ID: DTXSID8044707
• Nikkaji Number: J43.199K
• Wikidata: Q18651888
• Metabolomics Workbench ID: 4499
• ChEMBL ID: CHEMBL32605
• Mol file: 629-54-9.mol

Synonyms:hexadecanamide;palmitamide

Chemical Property of Hexadecanamide

Chemical Property:

• Vapor Pressure: 2.3E-06mmHg at 25°C
• Melting Point: 106°C
• Refractive Index: 1.4545 (estimate)
• Boiling Point: 236 °C / 12mmHg
• PKA: 16.61±0.40(Predicted)
• Flash Point: 191.1oC
• PSA: 43.09000
• Density: 0.87g/cm3
• LogP: 5.65330
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 14
• Exact Mass: 255.256214676
• Heavy Atom Count: 18
• Complexity: 180

Purity/Quality:

98%,99%, ^*data from raw suppliers

Hexadecanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Amides, Other
• Canonical SMILES: CCCCCCCCCCCCCCCC(=O)N
• Uses: Hexadecanamide can be used to prepare tissue regeneration.

Technology Process of Hexadecanamide

There total 20 articles about Hexadecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-hexadecylcarboxylic acid (57-10-3) → Palmitamide (629-54-9)

Guidance literature:

With ammonia; zircornium(IV) n-propoxide; at 165 ℃; for 7h; Reagent/catalyst;

Reference yield: 92.0%

palmitic acid azide (77165-63-0) → Palmitamide (629-54-9)

Guidance literature:

With benzyltriethylammonium tetrathiomolybdate; In water; acetonitrile; at 25 ℃; for 1h;

DOI:10.1021/jo00128a048

Reference yield: 91.0%

hexadecanoic acid methyl ester (112-39-0) + ammonia (7664-41-7) → Palmitamide (629-54-9)

Guidance literature:

sodium methylate; In ethylene glycol; at 65 ℃; for 8h; Conversion of starting material;

upstream raw materials:

hexadecanoic acid ethyl ester

palmitic acid azide

formamide

1-hexadecylcarboxylic acid

Downstream raw materials:

1-p-tolyl-hexadecan-1-one

N-hydroxymethyl-palmitamide

1-pentadecylamine

hexadecanophenone

Refernces

• 1、 Ghidini, Andrea,Scalvini, Laura,Palese, Francesca,Lodola, Alessio,Mor, Marco,Piomelli, Daniele. "Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase". . p. 1411 - 1423. Retrieved 2021/07/17.
• 2、 Jamil, Md. A. R.,Siddiki, S. M. A. Hakim,Touchy, Abeda Sultana,Rashed, Md. Nurnobi,Poly, Sharmin Sultana,Jing, Yuan,Ting, Kah Wei,Toyao, Takashi,Maeno, Zen,Shimizu, Ken-ichi. "Selective Transformations of Triglycerides into Fatty Amines, Amides, and Nitriles by using Heterogeneous Catalysis". . p. 3115 - 3125. Retrieved 2019/04/26.