acetyl hypofluorite

Base Information

• Chemical Name: acetyl hypofluorite
• CAS No.: 78948-09-1
• Molecular Formula: C2H3 F O2
• Molecular Weight: 78.043
• DSSTox Substance ID: DTXSID70229403
• Nikkaji Number: J456.236D
• Wikidata: Q83109634
• Mol file: 78948-09-1.mol

Synonyms:Acetylhypofluorite

Chemical Property of acetyl hypofluorite

Chemical Property:

• Vapor Pressure: 920mmHg at 25°C
• Melting Point: -96 °C
• Boiling Point: 19.9°C at 760 mmHg
• PSA: 26.30000
• Density: 1.107g/cm³
• LogP: 0.43400
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 78.01170750
• Heavy Atom Count: 5
• Complexity: 42.9

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OF

Technology Process of acetyl hypofluorite

There total 11 articles about acetyl hypofluorite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

acetic acid (64-19-7,77671-22-8) → acetyl hypofluorite (78948-09-1)

Guidance literature:

With fluorine; sodium fluoride; In trichlorofluoromethane; at -78 ℃;

DOI:10.1039/c39810000443

Reference yield:

acetic acid (64-19-7,77671-22-8) → acetyl fluoride (557-99-3) + acetyl hypofluorite (78948-09-1)

Guidance literature:

With potassium acetate; fluorine;

DOI:10.1021/ja00309a016

Reference yield:

sodium acetate (127-09-3) → acetyl hypofluorite (78948-09-1)

Guidance literature:

With trichlorofluoromethane; fluorine; acetic acid; at -78 ℃;

DOI:10.1016/S0040-4039(00)94583-0

upstream raw materials:

potassium acetate

sodium acetate

sodium dihydrogen triacetate

acetic acid

Downstream raw materials:

2-methoxypyridine

2-acetoxypyridine

2-methoxy,3-chloropyridine

2-ethoxypyridine

Refernces

• 1、 Rozen, Shlomo,Lerman, Ori,Kol, Moshe. "Acetyl Hypofluorite, the First Member of a New Family of Organic Compounds". . p. 443 - 444. Retrieved 1981.
• 2、 -. "METHODS AND COMPOUNDS USING IN-LOOP FLUORINATION". Page/Page column 13-14. . Retrieved 2020/11/12.
• 3、 Vints, Inna,Gatenyo, Julia,Rozen, Shlomo. "Fluorination of aryl boronic acids using acetyl hypofluorite made directly from diluted fluorine". . p. 11794 - 11797. Retrieved 2014/01/06.