2-CHLORO-3-METHYL-QUINOXALINE

Base Information

• Chemical Name: 2-CHLORO-3-METHYL-QUINOXALINE
• CAS No.: 32601-86-8
• Molecular Formula: C9H7ClN2
• Molecular Weight: 178.621
• Hs Code.: 29339900
• Mol file: 32601-86-8.mol

Synonyms:NSC 38593;

Chemical Property of 2-CHLORO-3-METHYL-QUINOXALINE

Chemical Property:

• Vapor Pressure: 0.0205mmHg at 25°C
• Melting Point: 91-93℃
• Refractive Index: 1.643
• Boiling Point: 259.9 °C at 760 mmHg
• PKA: -1.14±0.48(Predicted)
• Flash Point: 136.1 °C
• PSA: 25.78000
• Density: 1.292 g/cm³
• LogP: 2.59160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-3-methylquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-CHLORO-3-METHYL-QUINOXALINE

There total 8 articles about 2-CHLORO-3-METHYL-QUINOXALINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-methyl-2-oxo-1,2-dihydroquinoxaline (14003-34-0) → 2-chloro-3-methylquinoxaline (32601-86-8)

Guidance literature:

With trichlorophosphate; at 120 ℃; for 5h;

DOI:10.1016/j.ejmech.2016.08.010

Reference yield: 85.7%

3-methylquinoxalin-2-ol (14003-34-0) → 2-chloro-3-methylquinoxaline (32601-86-8)

Guidance literature:

With phosphorus trichloride; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h; Reagent/catalyst; Temperature; Inert atmosphere;

Reference yield: 6.0%

2-chloroquinoxaline (1448-87-9) + 2-(ethoxycarbonothioylthio)acetic acid (25554-84-1) → 2-chloro-3-methylquinoxaline (32601-86-8)

Guidance literature:

With dilauryl peroxide; In ethyl acetate; for 6h; Reflux; Inert atmosphere;

DOI:10.1021/acs.orglett.8b00190

upstream raw materials:

3-methyl-2-oxo-1,2-dihydroquinoxaline

3-methylquinoxalin-2-ol

2-oxo-propionic acid ethyl ester

1,2-diamino-benzene

Downstream raw materials:

2-methyl-3-phenylsulphonylquinoxaline

2-methyl-3-(phenylthio)quinoxaline

3-Chloroquinoxaline-2-carboxylic acid

Refernces

• 1、 Amanzougaghene, Nadia,Amrane, Dyhia,Azas, Nadine,Azqueta, Amaya,Mazier, Dominique,Primas, Nicolas,Sanz-Serrano, Julen,Tajeri, Shahin,Vanelle, Patrice,Verhaeghe, Pierre,Arnold, Christophe-Sébastien,Botté, Cyrille,Hutter, Sébastien,Louis, Béatrice. "Antiplasmodial 2-thiophenoxy-3-trichloromethyl quinoxalines target the apicoplast of Plasmodium falciparum". . . Retrieved 2021/08/09.
• 2、 El Newahie, Aliya M.S.,Nissan, Yassin M.,Ismail, Nasser S.M.,Abou El Ella, Dalal A.,Khojah, Sohair M.,Abouzid, Khaled A.M.. "Design and synthesis of new quinoxaline derivatives as anticancer agents and apoptotic inducers". . . Retrieved 2019/04/03.