Tert-butyl piperidin-4-ylcarbamate

Base Information Edit

Chemical Name:Tert-butyl piperidin-4-ylcarbamate
CAS No.:73874-95-0
Molecular Formula:C10H20N2O2
Molecular Weight:236.742
Hs Code.:29339900
European Community (EC) Number:616-026-6
DSSTox Substance ID:DTXSID20352356
Nikkaji Number:J1.522.015E
Wikidata:Q72448380
Mol file:73874-95-0.mol

Synonyms:73874-95-0;4-Boc-aminopiperidine;tert-butyl piperidin-4-ylcarbamate;4-N-Boc-Aminopiperidine;4-(N-Boc-amino)piperidine;4-(Boc-amino)piperidine;tert-butyl N-(piperidin-4-yl)carbamate;tert-butyl N-piperidin-4-ylcarbamate;4-(tert-Butoxycarbonylamino)piperidine;piperidin-4-yl-carbamic acid tert-butyl ester;4-n-boc-amino-piperidine;4-(boc-amino)-piperidine;MFCD00798171;4-N-(tert-butoxycarbonyl)aminopiperidine;4-(n-boc amino)piperidine;4-(n-tert-butoxycarbonylamino)piperidine;t-butyl piperidin-4-ylcarbamate;tert-butylpiperidine-4-ylcarbamate;Carbamic acid, 4-piperidinyl-, 1,1-dimethylethyl ester;Piperidin-4-ylcarbamic acid tert-butyl ester;MixCom4_000233;4-bocaminopiperidine;tert-butyl N-(4-piperidyl)carbamate;4-(tert-Butoxycarbonyl)-aMinopiperidine;4-BOCamino-piperidine;4-Boc-amino-piperidine;(tert-butoxy)-N-(4-piperidyl)carboxamide;n-boc piperidin-4-amine;Maybridge2_000784;4-n-boc-amino piperidine;4(BOC-amino)-piperidine;4-(BOC amino)piperidine;4-(Boc-amino) piperidine;4(n-boc amino) piperidine;4-(n-boc-amino) piperidine;4-(n-boc-amino)-piperidine;SCHEMBL56856;4-(N-BOC amino) piperidine;4-(N-BOC amino)-piperidine;tert-butyl 4-piperidylcarbamate;t-butyl-piperidin-4-ylcarbamate;4-t-butoxycarbonylaminopiperidine;tert-butyl 4-piperidinylcarbamate;tert-butyl 4-piperidyl-carbamate;tert-butyl-4-piperidinylcarbamate;tert-butylpiperidin-4-ylcarbamate;DTXSID20352356;4-t-butoxycarbonylamino-piperidine;4-t-butyloxycarbonylaminopiperidine;tert-butyl 4-piperidinyl-carbamate;tert-butyl-piperidin-4-ylcarbamate;4-(N-Boc-amino)piperidine, 96%;4-(t-butoxycarbonylamino)piperidine;4-tert-butoxycarbonylaminopiperidine;BCP04901;CS-D0638;tert-butyl piperidin-4-yl-carbamate;tert-butyl piperidine-4-ylcarbamate;tert-butyl(piperidin-4-yl)carbamate;4-ter-Butoxycarbonylamino-piperidine;4-(tertbutoxycarbonylamino)piperidine;CCG-54860;STK501502;4-tert-Butyloxycarbonylaminopiperidine;tert-butyl (piperidin-4-yl)carbamate;tert-butyl n-(piperid-4-yl)carbamate;4-(tert-butoxycarbonyl)aminopiperidine;AKOS000169674;SB10002;1,1-dimethyethyl 4-piperidinylcarbamate;4-(tert-butoxycarbonylamino)-piperidine;IDI1_001977;1,1-dimethylethyl 4-piperidinylcarbamate;4-[(tert-butoxycarbonyl)amino]piperidine;(Tert-butoxy)-N-(4-piperidy)carboxamide;BP-10838;SY002020;1,1-dimethylethyl piperidin-4-ylcarbamate;4-[(tert-butyloxycarbonyl)amino]piperidine;O-tert-butyl N-(piperidin-4-yl)carbamate;piperidin-4-yl-carbamic acid t-butyl ester;A9507;AM20100714;B2319;BB 0240365;FT-0601658;EN300-36333;piperidin-4-yl carbamic acid tert-butyl ester;piperidin-4-yl-carbamic acid-tert-butyl ester;piperidin-4-yl-carbamic acid, tert-butyl ester;piperidine-4-yl-carbamic acid tert-butyl ester;6X-5030;SR-01000004625;4-piperidinylcarbamic acid, 1,1-dimethylethyl ester;Q-103050;SR-01000004625-1;SR-01000004625-2;4-piperidinyl-carbamic acid, 1,1-dimethylethyl ester;BRD-K22624842-001-01-6;F1989-0076;Z285919714;4-N-BOC-Aminopiperidine

Suppliers and Price of Tert-butyl piperidin-4-ylcarbamate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(N-tert-Butoxycarbonylamino)piperidine
2.5g
$ 120.00

TCI Chemical
4-(tert-Butoxycarbonylamino)piperidine >98.0%(GC)(T)
1g
$ 12.00

TCI Chemical
4-(tert-Butoxycarbonylamino)piperidine >98.0%(GC)(T)
5g
$ 23.00

SynQuest Laboratories
4-Aminopiperidine, 4-Boc protected 97%
25 g
$ 52.00

SynQuest Laboratories
4-Aminopiperidine, 4-Boc protected 97%
100 g
$ 136.00

Sigma-Aldrich
4-(N-Boc-amino)piperidine 96%
5g
$ 121.00

Sigma-Aldrich
4-(N-Boc-amino)piperidine 96%
1g
$ 49.80

Sigma-Aldrich
4-(N-Boc-amino)piperidine 96%
25g
$ 92.70

Oakwood
4-N-Boc-Aminopiperidine
5g
$ 13.00

Oakwood
4-N-Boc-Aminopiperidine
1g
$ 11.00

Total 172 raw suppliers

Chemical Property of Tert-butyl piperidin-4-ylcarbamate Edit

Chemical Property:

Appearance/Colour:Off-white solid
Vapor Pressure:0.000854mmHg at 25°C
Melting Point:162-166 °C
Boiling Point:304.8 °C at 760 mmHg
PKA:12.39±0.20(Predicted)
Flash Point:138.2 °C
PSA：50.36000
Density:1.02 g/cm³
LogP:1.98280
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Sensitive.:Air Sensitive
Solubility.:soluble in Methanol
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:200.152477885
Heavy Atom Count:14
Complexity:193

Purity/Quality:

98%, ^*data from raw suppliers

4-(N-tert-Butoxycarbonylamino)piperidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36-37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CCNCC1
Description 4-(N-Boc-amino)piperidone may be used as a functionalization reagent for introduction of a primary and a tertiary amino group to poly(2-isopropyl-2-oxazoline. It can also be used as pharma building block. It is used in the synthesis of a piperidine-4-carboxamide CCR5 antagonist with potent anti-HIV 1-activity. It is an intermediate for the synthesis of various pharmaceutical and biologically active compounds, including inhibitors and therapeutic agents. It is used for the synthesis of diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 Antagonists.
Uses Pharma building block.

Technology Process of Tert-butyl piperidin-4-ylcarbamate

There total 16 articles about Tert-butyl piperidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 73889-19-7
tert-butyl (1-benzylpiperidin-4-yl)carbamate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 12h;

Reference yield: 91.0%

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Guidance literature:

Reference yield: 90.7%

: C₁₇H₂₄N₂O₂

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 70 ℃; for 4h; under 6000.6 - 7500.75 Torr; Reagent/catalyst; Temperature;