1,4-DIBROMO-2-FLUOROBENZENE

Base Information

• Chemical Name: 1,4-DIBROMO-2-FLUOROBENZENE
• CAS No.: 1435-52-5
• Molecular Formula: C6H3Br2F
• Molecular Weight: 253.896
• Hs Code.: 29039990
• Mol file: 1435-52-5.mol

Synonyms:NSC 402971;2-Fluoro-1,4-dibromobenzene;1,4-Dibromo-2-fluorobenzene;2,5-Dibromo-1-fluorobenzene;

Chemical Property of 1,4-DIBROMO-2-FLUOROBENZENE

Chemical Property:

• Appearance/Colour: white crystalline mass
• Melting Point: 33-36 °C(lit.)
• Refractive Index: 1.5770 (estimate)
• Boiling Point: 213.858 °C at 760 mmHg
• Flash Point: 101.667 °C
• PSA: 0.00000
• Density: 2.014 g/cm³
• LogP: 3.35070
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Insoluble in water.

Purity/Quality:

98% ^*data from raw suppliers

1,4-Dibromo-2-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,4-Dibromo-2-fluorobenzene was used in preparation of 1,4-bis(2-hydroxy-2-methyl-3-butynyl)-2-fluorobenzene.

Technology Process of 1,4-DIBROMO-2-FLUOROBENZENE

There total 2 articles about 1,4-DIBROMO-2-FLUOROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dibromoaniline (3638-73-1) → 2,5-dibromofluorobenzene (1435-52-5)

Guidance literature:

With hydrogenchloride; tetrafluoroboric acid; sodium nitrite; Erhitzen des Reaktionsprodukts auf 197grad;

Reference yield:

→ 2,5-dibromofluorobenzene (1435-52-5)

Guidance literature:

Reference yield: 97.0%

2,5-dibromofluorobenzene (1435-52-5) + trimethylsilylacetylene (1066-54-2) → ((2-fluoro-1,4-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 45 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol8029593

upstream raw materials:

2,5-dibromoaniline

Downstream raw materials:

2-fluorobiphenyl

2'-fluoro-1,1':4',1''-terphenyl

1,4-dibromo-2-hydroxyethoxybenzene

4-bromo-2-fluorobenzaldehyde

Refernces