Veralipride

Base Information

• Chemical Name: Veralipride
• CAS No.: 66644-81-3
• Molecular Formula: C17H25N3O5S
• Molecular Weight: 383.469
• Hs Code.: 2935009090
• European Community (EC) Number: 266-435-5
• UNII: S7064109UD
• DSSTox Substance ID: DTXSID6046268
• Nikkaji Number: J19.193K
• Wikipedia: Veralipride
• Wikidata: Q3564216
• NCI Thesaurus Code: C152857
• Metabolomics Workbench ID: 154322
• ChEMBL ID: CHEMBL2105581
• Mol file: 66644-81-3.mol

Synonyms:Agréal;Agreal;Menofel;N-(1-allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide;Veraligral;veralipride;veralipride monohydrochloride

Chemical Property of Veralipride

Chemical Property:

• Melting Point: 128 °C
• Refractive Index: 1.547
• PKA: 10.02±0.60(Predicted)
• PSA: 119.34000
• Density: 1.23 g/cm³
• LogP: 2.84130
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly)
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 383.15149208
• Heavy Atom Count: 26
• Complexity: 592

Purity/Quality:

99% ^*data from raw suppliers

Veralipride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)C(=O)NCC2CCCN2CC=C)S(=O)(=O)N
• Uses: Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gaining interest as a non-hormonal treatment for climacteric flushing. Labelled Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gain ing interest as a non-hormonal treatment for climacteric flushing.
• Therapeutic Function: Menopause treatment

Technology Process of Veralipride

There total 4 articles about Veralipride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.8%

→ Veralipride (66644-81-3)

Guidance literature:

Reference yield: 68.0%

2,3-dimethoxy-5-sulfonamidobenzoic acid methyl ester (66644-82-4) + 1-allyl-2-aminomethyl-pyrrolidine (26116-13-2) → Veralipride (66644-81-3)

Guidance literature:

In hydrogenchloride; water; ethylene glycol;

Reference yield: 61.0%

2,3-dimethoxy-5-sulphamoyl benzoic acid (66644-80-2) + 1-allyl-2-aminomethyl-pyrrolidine (26116-13-2) → Veralipride (66644-81-3)

Guidance literature:

With triethylamine; In 2-ethyl-5-phenylisoxazolium-3'-sulphonate; ethyl acetate; acetonitrile;

upstream raw materials:

Carbonyldiimidazole

2,3-dimethoxy-5-sulphamoyl benzoic acid

1-allyl-2-aminomethyl-pyrrolidine

2,3-dimethoxy-5-sulfonamidobenzoic acid methyl ester

Downstream raw materials:

[Cu(N-((1-allyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-2-veretramide)2Cl₂(H₂O)2]

[Zn(N-((1-allyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-2-veretramide)2Cl₂(H₂O)2]

Refernces