Benzydamine hydrochloride

Base Information

• Chemical Name: Benzydamine hydrochloride
• CAS No.: 132-69-4
• Molecular Formula: C19H23N3O^.HCl
• Molecular Weight: 345.872
• Hs Code.: 2933990090
• European Community (EC) Number: 205-076-0
• NSC Number: 759276
• UNII: K2GI407R4Q
• DSSTox Substance ID: DTXSID1045293
• Wikidata: Q27281858
• NCI Thesaurus Code: C1581
• ChEMBL ID: CHEMBL1528134
• Mol file: 132-69-4.mol

Synonyms:Benzidamine;Benzindamine;Benzydamine;Benzydamine Hydrochloride;Benzydamine Monohydrochloride;Difflam;Hydrochloride, Benzydamine;Lonol;Monohydrochloride, Benzydamine;Novo Benzydamine;Novo-Benzydamine;Opalgyne;PMS Benzydamine;PMS-Benzydamine;ratio Benzydamine;ratio-Benzydamine;Rosalgin;Sun Benz;Sun-Benz;Tantum;Tantum Topico

Chemical Property of Benzydamine hydrochloride

Chemical Property:

• Appearance/Colour: the white crystalline powder
• Vapor Pressure: 3.64E-09mmHg at 25°C
• Melting Point: 147-153 °C
• Boiling Point: 474.4 °C at 760 mmHg
• Flash Point: 240.7 °C
• PSA: 30.29000
• LogP: 4.21710
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Soluble in water, ethanol, chloroform, n-butanol or DMSO /n
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 345.1607901
• Heavy Atom Count: 24
• Complexity: 344

Purity/Quality:

99%min ^*data from raw suppliers

Benzydamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Uses -> Pharmaceuticals
• Canonical SMILES: CN(C)CCCOC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3.Cl
• Recent ClinicalTrials: Preoperative Aspirin and Benzydamine Hydrochloride Gargles on Severity and Duration of Post-Operative Sore Throat
• Recent EU Clinical Trials: Phase IV study on the feasibility of a preventative/therapeutic approach with Benzydamine Oromucosal solution in radiation-induced Oral Mucositis (OM) in patients with head and neck cancer (HNC)
• Description: Benzydamine hydrochloride is a non-steroidal antiinflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer and caused occupational contact dermatitis in a nurse.
• Uses: A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties. anticholinergic A nonsteroidal anti-inflammatory with local anesthetic properties. Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis.
• Therapeutic Function: Analgesic, Antiinflammatory, Antipyretic

Technology Process of Benzydamine hydrochloride

There total 1 articles about Benzydamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.6%

chlorobase + pyrographite (7440-44-0) + 1-benzyl-3-indazolol sodium salt (13185-09-6) + 3-(Dimethylamino)propyl chloride (109-54-6) → benzydamine hydrochloride (132-69-4)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; hexane; water;

Reference yield:

2-(2-dimethylamino-ethoxy)-N,N-dimethylamino-methylene benzamide + benzydamine hydrochloride (132-69-4) → 2-{2-[2-(N,N-Dimethylamino)ethyl]oxy-phenyl}-4-phenyl-1,3,5-triazine

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; ethyl acetate;

Reference yield:

benzydamine hydrochloride (132-69-4) + Phenylbutazon Natriumsalz (2531-05-7) → Phenylbutazon-Benzydamin-Salz (37598-92-8)

Guidance literature:

In acetone; for 0.166667h; Heating;

upstream raw materials:

pyrographite

1-benzyl-3-indazolol sodium salt

3-(Dimethylamino)propyl chloride

Downstream raw materials:

Phenylbutazon-Benzydamin-Salz

N-Demethyl-Benzydamine

Benzydamine N-Oxide

Refernces