1-NAPHTHYLMAGNESIUM BROMIDE

Base Information

• Chemical Name: 1-NAPHTHYLMAGNESIUM BROMIDE
• CAS No.: 703-55-9
• Molecular Formula: C10H7BrMg
• Molecular Weight: 231.375
• Hs Code.: 29319090
• Mol file: 703-55-9.mol

Synonyms:1-Naphthylmagnesiumbromide (6CI);Magnesium, bromo-1-naphthyl- (7CI,8CI);1-Naphthalenylmagnesiumbromide;1-Naphthomagnesium bromide;a-Naphthylmagnesium bromide;bromo-(1-naphthyl)magnesium;magnesium, bromo-1-naphthalenyl-;Bromo(1-naphthyl)magnesium;

Chemical Property of 1-NAPHTHYLMAGNESIUM BROMIDE

Chemical Property:

• Appearance/Colour: Light yellow to yellow slurry or solution
• Vapor Pressure: 0.159mmHg at 25°C
• Boiling Point: 65 °C
• Flash Point: -17 °C
• PSA: 0.00000
• Density: 0.908 g/mL at 25 °C
• LogP: 3.48560
• Storage Temp.: water-free area
• Sensitive.: Air & Moisture Sensitive

Purity/Quality:

99.0% ^*data from raw suppliers

1-Naphthylmagnesium bromide solution 0.25?M slurry in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F; C
• Hazard Codes: F,C,Xn
• Statements: 11-14-19-22-34-40-36/37/38
• Safety Statements: 16-26-33-36/37/39-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Naphthylmagnesium bromide can be used:To prepare unsymmetrical chiral diene ligands, which are applicable in asymmetric transformation reactions.As a starting material in the synthesis of methyl (2Z,4E)-2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate, a naphthylnitrobutadiene based anti-proliferative compound.

Technology Process of 1-NAPHTHYLMAGNESIUM BROMIDE

There total 8 articles about 1-NAPHTHYLMAGNESIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-methylmorpholine-N-oxide (NMO) + 1-Bromonaphthalene (90-11-9) → 1-naphthylmagnesiumbromide (703-55-9)

Guidance literature:

With tetrapropylammonium perruthennate; magnesium; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

1-Bromonaphthalene (90-11-9) → 1-naphthylmagnesiumbromide (703-55-9)

Guidance literature:

With magnesium; ethylene dibromide; In diethyl ether; 1) reflux, 2) r.t., 1 h;

DOI:10.1021/jo00028a043

Reference yield:

1-Bromonaphthalene (90-11-9) + 6-(2-dimethylamino-ethoxy)-3,4-dihydro-2H-naphthalen-1-one (62325-06-8) → 1-naphthylmagnesiumbromide (703-55-9)

Guidance literature:

With ammonium chloride; magnesium; In tetrahydrofuran;

upstream raw materials:

1-Bromonaphthalene

6-(2-dimethylamino-ethoxy)-3,4-dihydro-2H-naphthalen-1-one

4-bromo-2,3-dihydroinden-1-one

magnesium

Downstream raw materials:

3-(Naphth-1-yl)propan-1-ol

4-(1-naphthyl)-4-oxobutanoic acid

acetic acid-[2-(hydroxy-di-[1]naphthyl-methyl)-anilide]

2-(4-ethoxy-phenyl)-3-[1]naphthyl-inden-1-one

Refernces

• 1、 -. "Method for asymmetrically synthesizing (R)-cinacalcet". Paragraph 0026-0028. . Retrieved 2019/03/28.
• 2、 -. "METHOD OF PRODUCING AN ORGANIC SILICON COMPOUND". Paragraph 0053. . Retrieved 2013/07/19.