Senbusine C

Base Information

• Chemical Name: Senbusine C
• CAS No.: 80665-72-1
• Molecular Formula: C₂₄H₃₉NO₇
• Molecular Weight: 453.576
• European Community (EC) Number: 683-232-0
• Wikidata: Q110080570
• Mol file: 80665-72-1.mol

Synonyms:Fuziline;Senbusine C;80665-72-1;11-Ethyl-6,18-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,7,8,16-tetrol;15-Epinagarine;15-Hydroxyneoline;CHEBI:183920;1ST157888;NS00067921

Chemical Property of Senbusine C

Chemical Property:

• Vapor Pressure: 9.8E-17mmHg at 25°C
• Melting Point: 206-207oC
• Boiling Point: 596.9oC at 760 mmHg
• PKA: 12.78±0.70(Predicted)
• Flash Point: 314.8oC
• PSA: 111.85000
• Density: 1.36g/cm3
• LogP: -0.58930
• XLogP3: -1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 453.27265258
• Heavy Atom Count: 32
• Complexity: 783

Purity/Quality:

95%-98% ^*data from raw suppliers

Fuziline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1CC2(CCC(C34C2C(C(C31)C5(C6C4CC(C6O)C(C5O)OC)O)OC)O)COC
• Uses: Fuziline is a drug used as an analyte or reagent for research on the cardiovascular system and therapeutic use.

Technology Process of Senbusine C

There total 14 articles about Senbusine C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

C28H41NO9 (80680-12-2) → 15-β-hydroxyneoline (80665-72-1,80665-73-2,83694-44-4) + 15-α-ydroxyneoline (80665-72-1,80665-73-2,83694-44-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

Reference yield: 64.0%

C28H41NO9 (80680-12-2) → 15-β-hydroxyneoline (80665-72-1,80665-73-2,83694-44-4) + 15-α-ydroxyneoline (80665-72-1,80665-73-2,83694-44-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

Reference yield:

pyrodelphisine (81525-79-3) → nagarine (80665-72-1,80665-73-2,83694-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / methanol / 2 h / Heating

2: 1.) OsO₄, Na₂S₂ / 1.) pyridine, dioxane, RT, 1 h, 2.) pyridine, dioxane, water, 15 min

With potassium hydroxide; osmium(VIII) oxide; sodium disulfide; In methanol;

upstream raw materials:

pyroneoline

pyrodelphisine

delphisine

C₂₈H₄₁NO₉

Refernces

• 1、 Mody, Naresh V.,Pelletier, S. William,Szu-Ying, Chen. "THE STRUCTURE AND PARTIAL SYNTHESIS OF NAGARINE. A NOVEL ALKALOID FROM THE CHINESE DRUG, ACONITUM NAGARUM VAR. HETEROTRICHUM F. DIELSIANUM W. T. WANG". . p. 91 - 94. Retrieved 2007/10/02.