(R)-(-)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine

Base Information

• Chemical Name: (R)-(-)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine
• CAS No.: 144119-12-0
• Molecular Formula: C18H21NO
• Molecular Weight: 267.3654
• Hs Code.: 29339900
• European Community (EC) Number: 635-081-7
• Nikkaji Number: J383.006C
• Mol file: 144119-12-0.mol

Synonyms:144119-12-0;(R)-(1-Methylpyrrolidin-2-yl)diphenylmethanol;(R)-(-)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine;[(2R)-1-methylpyrrolidin-2-yl]-diphenylmethanol;MFCD00145217;1,1-diphenyl-n-methyl-d-prolinol;1,1,1-Diphenyl-(N-methyl-pyrroline-2yl)-methanol;(r)-alpha,alpha-diphenylmethylprolinol;d-diphenylmethylprolinol;[(2R)-1-methylpyrrolidin-2-yl]diphenylmethanol;(r)-a,a-diphenylmethylprolinol;SCHEMBL7922116;TD8074;AKOS007930843;CS-W012413;alpha,alpha-Diphenyl-N-methyl-D-prolinol;AS-69024;H0784;((r)-1-methylpyrrolidin-2-yl)diphenylmethanol;(R)-1-Methyl-2-(diphenylhydroxymethyl)pyrrolidine;(r)-a,a-n-methyl diphenyl-2-pyrrolidine methanol;(r)-n-methyl-a,a-diphenyl-2-pyrrolidine methanol;1,1-diphenyl-(n-methyl-pyrroline-2-yl)-methanol;(R)-(-)-Diphenyl(1-methylpyrrolidin-2-yl)methanol;Q-102755;(2r)-1-methyl-alpha,alpha-diphenyl-2-pyrrolidinemethanol;(R)-alpha,alpha-Diphenyl-N-methyl-2-pyrrolidinemethanol;(r)-n-methyl-alpha,alpha-diphenyl-2-pyrrolidinemethanol;(2R)-N-Methyl-alpha,alpha-diphenyl-2-pyrrolidinemethanol;(R)-N-Methyl-alpha,alpha-diphenyl-2-pyrrolidine methanol;2-Pyrrolidinemethanol, 1-methyl-alpha,alpha-diphenyl-, (2R)-;alpha,alpha-Diphenyl-N-methyl-D-prolinol, >=99% (sum of enantiomers, GC)

Chemical Property of (R)-(-)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine

Chemical Property:

• Appearance/Colour: white to off-white crystalline powder
• Vapor Pressure: 2.39E-07mmHg at 25°C
• Melting Point: 68-71 °C
• Refractive Index: -55 ° (C=1, CHCl3)
• Boiling Point: 406.791 °C at 760 mmHg
• PKA: 13.15±0.29(Predicted)
• Flash Point: 196.766 °C
• PSA: 23.47000
• Density: 1.116 g/cm³
• LogP: 2.95460
• Storage Temp.: 0-6°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 267.162314293
• Heavy Atom Count: 20
• Complexity: 287

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-(1-Methylpyrrolidin-2-yl)diphenylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O
• Isomeric SMILES: CN1CCC[C@@H]1C(C2=CC=CC=C2)(C3=CC=CC=C3)O

Technology Process of (R)-(-)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine

There total 3 articles about (R)-(-)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl sulfate (77-78-1) + (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole (112022-83-0,133261-83-3) → (R)-(+)-1-methyl-α,α-diphenyl-2-pyrrolidinemethanol (144119-12-0)

Guidance literature:

With potassium carbonate; In water;

DOI:10.1016/j.tetlet.2007.01.118

Reference yield:

phenylmagnesium bromide + 1-ethyl methyl (2R)-pyrrolidine-1,2-dicarboxylate (185246-66-6) → (R)-(+)-1-methyl-α,α-diphenyl-2-pyrrolidinemethanol (144119-12-0)

Guidance literature:

phenylmagnesium bromide; 1-ethyl methyl (2R)-pyrrolidine-1,2-dicarboxylate; In tetrahydrofuran; Heating;

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/j.tetasy.2005.06.010

Reference yield:

→ (R)-(+)-1-methyl-α,α-diphenyl-2-pyrrolidinemethanol (144119-12-0)

Guidance literature:

upstream raw materials:

1-ethyl methyl (2R)-pyrrolidine-1,2-dicarboxylate

dimethyl sulfate

(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

Refernces

• 1、 Wu, Xiaoyu,Liu, Xinyuan,Zhao, Gang. "Catalyzed asymmetric aryl transfer reactions to aldehydes with boroxines as aryl source". . p. 2299 - 2305. Retrieved 2007/10/03.
• 2、 -. "PYRROLIDINE DERIVATIVES". . . Retrieved 2008/06/13.