(3-Fluorophenyl)hydrazine hydrochloride

Base Information

• Chemical Name: (3-Fluorophenyl)hydrazine hydrochloride
• CAS No.: 2924-16-5
• Molecular Formula: C6H7FN2^.HCl
• Molecular Weight: 162.594
• Hs Code.: 29280000
• European Community (EC) Number: 256-724-4
• DSSTox Substance ID: DTXSID60951847
• Mol file: 2924-16-5.mol

Synonyms:2924-16-5;3-Fluorophenylhydrazine hydrochloride;(3-Fluorophenyl)hydrazine hydrochloride;3-fluorophenylhydrazine hcl;3-Fluorophenylhydrazine, HCl;(3-Fluorophenyl)hydrazine HCl;Hydrazine, (3-fluorophenyl)-, monohydrochloride;m-fluorophenylhydrazine hydrochloride;MFCD00012934;(3-fluorophenyl)hydrazine;hydrochloride;EINECS 220-886-4;EINECS 256-724-4;50702-51-7;(3-Fluorophenyl)hydrazine monohydrochloride;SCHEMBL124910;DTXSID60951847;SKVGLOFWEJFQKU-UHFFFAOYSA-N;3-fluorophenylhydrazinehydrochloride;3-fluorophenyl hydrazine hydrochloride;AKOS001475862;AC-9806;CS-W017926;GS-6788;SB76547;ANDROST-5-EN-3B,7,17B-TRIOL;SY013472;3-Fluorophenylhydrazine hydrochloride, 97%;(3-fluorophenyl)hydrazine hydrochloride salt;AM20060206;FT-0615745;Hydrazine, (m-fluorophenyl)-, hydrochloride;EN300-54708;(3-fluoro-phenyl)-hydrazine hydrochloric acid salt;(3-Fluorophenyl)hydrazine--hydrogen chloride (1/1);Hydrazine, (3-fluorophenyl)-, hydrochloride (1:1);J-512555

Chemical Property of (3-Fluorophenyl)hydrazine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.0931mmHg at 25°C
• Melting Point: 268 °C (dec.)(lit.)
• Boiling Point: 226.7 °C at 760 mmHg
• Flash Point: 90.9 °C
• PSA: 38.05000
• LogP: 2.68660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform : DMSO = 1 : 1 (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 162.0360041
• Heavy Atom Count: 10
• Complexity: 87.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Fluorophenylhydrazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi,T
• Statements: 20/21/22-36/37/38-43-40-23/24/25
• Safety Statements: 26-37/39-45-36/37-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)F)NN.Cl
• Uses: 3-Fluorophenylhydrazine Hydrochloride can be used to synthesize compounds that are useful for the prophylaxis and treatment of pro-inflammatory cytokine mediated diseases, and in particular, p38 activity mediated inflammation and related conditions.

Technology Process of (3-Fluorophenyl)hydrazine hydrochloride

There total 4 articles about (3-Fluorophenyl)hydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

m-fluorophenylhydrazine (658-27-5) → 3-fluorophenylhydrazine hydrochloride (2924-16-5,50702-51-7)

Guidance literature:

With hydrogenchloride; In water; at 65 ℃;

Reference yield: 80.0%

1-Fluoro-3-iodobenzene (1121-86-4) → 3-fluorophenylhydrazine hydrochloride (2924-16-5,50702-51-7)

Guidance literature:

1-Fluoro-3-iodobenzene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 70.0%

→ 3-fluorophenylhydrazine hydrochloride (2924-16-5,50702-51-7)

Guidance literature:

upstream raw materials:

meta-fluoroaniline

m-fluorophenylhydrazine

1-Fluoro-3-iodobenzene

Downstream raw materials:

6H-[1,3]thiazolo-[5,4-e]-indole-7,8dione-8-[N-(3-fluorophenyl)hydrazone](Z-isomer)

2-(3-fluorophenyl)-8-{[2-(3-fluorophenyl)-3-methyl-4-oxo-2,4-dihydrochromeno[4,3-c]pyrazol-8-yl]methyl}-3-methyl-2,4-dihydrochromeno[4,3-c]pyrazol-4-one

ethyl 2-benzoylamino-3-[(3-fluorophenyl)hydrazono]propanoate

1,3-bis(3-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole

Refernces

• 1、 -. "Substituted indole urea derivative, synthetic method and application thereof". Paragraph 0072; 0095-0097. . Retrieved 2021/08/14.
• 2、 Kumar, Siripuram Vijay,Ma, Dawei. "Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water". supporting information. p. 1003 - 1006. Retrieved 2018/09/20.