1-Azabicyclo[3.1.0]hexane

Base Information

• Chemical Name: 1-Azabicyclo[3.1.0]hexane
• CAS No.: 285-76-7
• Molecular Formula: C₅H₉N
• Molecular Weight: 83.1332
• Hs Code.: 2933990090
• Mol file: 285-76-7.mol

Synonyms:1-Azabicyclo(3.1.0)hexane;1-Aza-bicyclo<3.1.0>hexan;

Chemical Property of 1-Azabicyclo[3.1.0]hexane

Chemical Property:

• Vapor Pressure: 40.6mmHg at 25°C
• Boiling Point: 98.1°C at 760 mmHg
• Flash Point: 3.3°C
• PSA: 3.01000
• Density: 1.03g/cm³
• LogP: 0.40230

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Azabicyclo[3.1.0]hexane

There total 3 articles about 1-Azabicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-(bromomethyl)pyrrolidine hydrobromide (3433-29-2) → 1-azabicyclo[3.1.0]hexane (285-76-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1248/cpb.57.1142

Reference yield: 30.0%

5-azidopent-1-ene (821-62-5) → 1-azabicyclo[3.1.0]hexane (285-76-7)

Guidance literature:

With C₂₀H₂₈B₂FeN₈*C₆H₆; In benzene-d6; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.organomet.6b00066

Reference yield:

→ 1-azabicyclo[3.1.0]hexane (285-76-7)

Guidance literature:

3-Hydroxy-piperidin, 1) wss. H2SO4; Erhitzen unter Destillation bis 200grad 2) wss. KOH; Dest.;

DOI:10.1021/jo01283a006

upstream raw materials:

2-(bromomethyl)pyrrolidine hydrobromide

5-azidopent-1-ene

Downstream raw materials:

1-benzyl-3-bromopiperidine

1-benzyl-3-chloropiperidine

1-benzoyl-2-chloromethylpyrrolidine

(3-chloropiperidin-1-yl)(phenyl)methanone

Refernces

• 1、 Hayashi, Kazuhiko,Kujime, Eiko,Katayama, Hajime,Sano, Shigeki,Shiro, Motoo,Nagao, Yoshimitsu. "Synthesis and reaction of 1-azabicyclo[3.1.0]hexane". experimental part. p. 1142 - 1146. Retrieved 2010/03/31.