3-EXO-AMINOBICYCLO[2.2.1]HEPT-5-ENE-2-EXO-CARBOXAMIDE

Base Information

• Chemical Name: 3-EXO-AMINOBICYCLO[2.2.1]HEPT-5-ENE-2-EXO-CARBOXAMIDE
• CAS No.: 105786-40-1
• Molecular Formula: C8H12 N2 O
• Molecular Weight: 152.19
• Hs Code.: 2924299090
• Mol file: 105786-40-1.mol

Synonyms:Bicyclo[2.2.1]hept-5-ene-2-carboxamide,3-amino-, (exo,exo)-

Chemical Property of 3-EXO-AMINOBICYCLO[2.2.1]HEPT-5-ENE-2-EXO-CARBOXAMIDE

Chemical Property:

• Appearance/Colour: WHITE CRYSTALLINE POWDER
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 235-253 °C
• Refractive Index: 1.4940 (estimate)
• Boiling Point: 350.598°C at 760 mmHg
• PKA: 16.32±0.40(Predicted)
• Flash Point: 165.836°C
• PSA: 69.11000
• Density: 1.222g/cm³
• LogP: 1.02170

Purity/Quality:

99% ^*data from raw suppliers

diexo-3-Aminobicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-EXO-AMINOBICYCLO[2.2.1]HEPT-5-ENE-2-EXO-CARBOXAMIDE

There total 1 articles about 3-EXO-AMINOBICYCLO[2.2.1]HEPT-5-ENE-2-EXO-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

ethyl 3-exo-aminobicyclo<2.2.1>hept-5-ene-2-exo-carboxylate (105786-36-5) → exo-3-aminobicyclo<2.2.1>hept-5-ene-exo-2-carboxamide (105786-40-1,402846-45-1)

Guidance literature:

With ammonia; In methanol; for 336h;

Reference yield: 95.0%

1-phenylmethyl-4-piperidone (3612-20-2) + exo-3-aminobicyclo<2.2.1>hept-5-ene-exo-2-carboxamide (105786-40-1,402846-45-1) → (4aR*,5R*,8S*,8aS*)-1′-benzyl-4a,5,8,8a-tetrahydro-1H-spiro[5,8-methanoquinazoline-2,4′-piperidin]-4(3H)-one

Guidance literature:

In ethanol; at 100 ℃; for 6h; under 7500.75 Torr; Flow reactor;

DOI:10.1002/ejoc.201800682

Reference yield: 53.0%

2-(4-toluoyl)benzoic acid (85-55-2) + exo-3-aminobicyclo<2.2.1>hept-5-ene-exo-2-carboxamide (105786-40-1,402846-45-1) → 4b-p-tolyl-6,9-methano-5ar,6c,9c,9ac-tetrahydroisoindolo[1,2-b]quinazoline-10,12-dione

Guidance literature:

With toluene-4-sulfonic acid; In chlorobenzene; for 3h; Heating;

DOI:10.1016/j.molstruc.2004.02.039

upstream raw materials:

ethyl 3-exo-aminobicyclo<2.2.1>hept-5-ene-2-exo-carboxylate

Downstream raw materials:

2-(4-chlorophenyl)-2,3,4ar,5c,8c,8ac-hexahydro-5,8-methano-4(1H)-quinazolinone

Refernces