4-(Trifluoromethyl)formanilide

Base Information

• Chemical Name: 4-(Trifluoromethyl)formanilide
• CAS No.: 74702-40-2
• Molecular Formula: C8H6F3NO
• Molecular Weight: 189.137
• Mol file: 74702-40-2.mol

Synonyms:4-(Trifluoromethyl)formanilide;N-[4-(Trifluoromethyl)phenyl]formamide;NSC 403005;NSC 403006;

Chemical Property of 4-(Trifluoromethyl)formanilide

Chemical Property:

• Vapor Pressure: 0.00515mmHg at 25°C
• Refractive Index: 1.499
• Boiling Point: 275.3 °C at 760 mmHg
• Flash Point: 120.3 °C
• PSA: 29.10000
• Density: 1.353 g/cm³
• LogP: 2.98260

Purity/Quality:

99% ^*data from raw suppliers

N-(4-(Trifluoromethyl)phenyl)Formamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Trifluoromethyl)formanilide

There total 17 articles about 4-(Trifluoromethyl)formanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-trifluoromethylphenylamine (455-14-1) + bis(trichloromethyl) carbonate (32315-10-9) → N-(4-(trifluoromethyl)phenyl)formamide (74702-40-2)

Guidance literature:

bis(trichloromethyl) carbonate; With triethylamine; In 1,4-dioxane; for 0.333333h; Inert atmosphere; Cooling with ice;

4-trifluoromethylphenylamine; In 1,4-dioxane; Inert atmosphere; Cooling with ice; Heating;

Reference yield: 95.0%

4-trifluoromethylphenylamine (455-14-1) + Glyoxilic acid (298-12-4) → N-(4-(trifluoromethyl)phenyl)formamide (74702-40-2)

Guidance literature:

With copper(II) acetate dihydrate; nickel(II) chloride hexahydrate; sodium perchlorate; caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 10h; Electrolysis;

DOI:10.1021/acs.orglett.8b00698

Reference yield: 94.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + 4-chlorobenzotrifluoride (98-56-6) → N-(4-(trifluoromethyl)phenyl)formamide (74702-40-2)

Guidance literature:

With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate; In 1,4-dioxane; at 90 ℃; for 18h; Inert atmosphere; Glovebox;

DOI:10.1002/chem.201302453

upstream raw materials:

4-trifluoromethylphenylamine

formic acid ethyl ester

hexanal

formamide

Downstream raw materials:

C₆H₄(CF₃)N(CHO)SCFCl₂

N-(4-Trifluoromethylphenyl)-N',N'-dimethyl-urea

5-trifluoromethyl-2-phenylsulfanyl-3-((methoxycarbonyl)(phenylsulfanyl)methyl)-1H-indole

methanol

Refernces

• 1、 Zhang, Yanmeng,Zhang, He,Gao, Ke. "Borane-Trimethylamine Complex as a Reducing Agent for Selective Methylation and Formylation of Amines with CO2". supporting information. p. 8282 - 8286. Retrieved 2021/10/25.
• 2、 Yu, Yang,Zhang, Yong,Sun, Chengyu,Shi, Lei,Wang, Wei,Li, Hao. "Copper promoted aerobic oxidative c(sp3)-c(sp3) bond cleavage of n-(2-(pyridin-2-yl)-ethyl)anilines". . p. 2725 - 2732. Retrieved 2020/03/11.