methanearsonous acid

Base Information

• Chemical Name: methanearsonous acid
• CAS No.: 25400-23-1
• Molecular Formula: CH₅AsO₂
• Molecular Weight: 123.971
• DSSTox Substance ID: DTXSID60180059
• Nikkaji Number: J622.642F
• Wikidata: Q27102648
• Metabolomics Workbench ID: 41956
• ChEMBL ID: CHEMBL4097463
• Mol file: 25400-23-1.mol

Synonyms:Methanearsonousacid (7CI,8CI); Methylarsonous acid; Monomethylarsonous acid

Chemical Property of methanearsonous acid

Chemical Property:

• Vapor Pressure: 0.0694mmHg at 25°C
• Boiling Point: 202.9°C at 760 mmHg
• PKA: 9.73±0.53(Predicted)
• Flash Point: 100.1°C
• PSA: 40.46000
• LogP: -0.91100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 123.950549
• Heavy Atom Count: 4
• Complexity: 13.5

Purity/Quality:

MonomethylarsonousAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[As](O)O
• Uses: Monomethylarsonous Acid is a highly toxic metabolite of inorganic arsenic. Monomethylarsonous Acid can induce malignant transformation of human cells. Chronic exposure to Monomethylarsonous Acid can increase the risk of developing multiple cancers in humans.

Technology Process of methanearsonous acid

There total 2 articles about methanearsonous acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylarsonic Acid (124-58-3) → monomethylarsonous acid (25400-23-1)

Guidance literature:

With GLUTATHIONE; fraction V; monomethylarsonic acid reductase; at 37 ℃; for 1h; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1021/tx010052h

Reference yield:

methylarsine oxide (593-58-8) → monomethylarsonous acid (25400-23-1)

Guidance literature:

With water;

DOI:10.1021/ac034868u

upstream raw materials:

methylarsonic Acid

methylarsine oxide

Refernces

• 1、 Zakharyan,Sampayo-Reyes,Healy,Tsaprailis,Board,Liebler,Aposhian. "Human monomethylarsonic acid (MMAv) reductase is a member of the glutathione-S-transferase superfamily". . p. 1051 - 1057. Retrieved 2001.
• 2、 Lu, Xiufen,Arnold, Lora L.,Cohen, Samuel M.,Cullen, William R.,Le, X. Chris. "Speciation of Dimethylarsinous Acid and Trimethylarsine Oxide in Urine from Rats Fed with Dimethylarsinic Acid and Dimercaptopropane Sulfonate". . p. 6463 - 6468. Retrieved 2003.