2-MORPHOLINOBENZOTHIAZOLE

Base Information

• Chemical Name: 2-MORPHOLINOBENZOTHIAZOLE
• CAS No.: 4225-26-7
• Molecular Formula: C₁₁H₁₂N₂OS
• Molecular Weight: 220.295
• Mol file: 4225-26-7.mol

Synonyms:Benzothiazole,2-morpholino- (6CI,7CI,8CI); 2-(4-Morpholino)benzothiazole;2-(4-Morpholinyl)benzothiazole; 2-Morpholinobenzothiazole

Chemical Property of 2-MORPHOLINOBENZOTHIAZOLE

Chemical Property:

• Vapor Pressure: 1.25E-05mmHg at 25°C
• Melting Point: 112-113 °C
• Boiling Point: 315°Cat760mmHg
• PKA: 3.19±0.10(Predicted)
• Flash Point: 160.8°C
• PSA: 53.60000
• Density: 1.228g/cm³
• LogP: 2.19790

Purity/Quality:

99% ^*data from raw suppliers

2-MORPHOLINO-1,3-BENZOTHIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-MORPHOLINOBENZOTHIAZOLE

There total 44 articles about 2-MORPHOLINOBENZOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 2-chlorobenzo[d][1,3]thiazole (615-20-3) → 4-(1,3-benzothiazol-2-yl)morpholine (4225-26-7)

Guidance literature:

With 1-C₁₀H₇Ni(P(C₆H₅)3)2Br; potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In toluene; at 23 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2011.03.038

Reference yield: 94.0%

morpholine (110-91-8,99108-56-2) + 1-iodo-2-isocyanobenzene → 4-(1,3-benzothiazol-2-yl)morpholine (4225-26-7)

Guidance literature:

With 1,10-Phenanthroline; potassium sulfide; copper(l) chloride; In N,N-dimethyl-formamide; at 100 ℃; for 2h; Schlenk technique;

DOI:10.1039/c6ob02413k

Reference yield: 93.0%

(1H-benzo[d][1,2,3]triazol-1-yl)(morpholino)methanethione (910642-54-5) → 4-(1,3-benzothiazol-2-yl)morpholine (4225-26-7)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In toluene; at 110 ℃; for 0.2h; Time; Inert atmosphere;

DOI:10.1021/jo4024107

upstream raw materials:

morpholine

2-chlorobenzo[d][1,3]thiazole

1-aminomorpholine

4-methyl-morpholine

Refernces

• 1、 Dong, Jinhuan,Hu, Junlin,Liu, Xiaoli,Sun, Shaoguang,Bao, Lan,Jia, Mengying,Xu, Xianxiu. "Ionic Reactivity of 2-Isocyanoaryl Thioethers: Access to 2-Halo and 2-Aminobenzothia/Selenazoles". . p. 2845 - 2852. Retrieved 2022/02/23.
• 2、 -. "Morpholine derivative oxidation ring-opening method and product thereof". Paragraph 0039; 0052-0054. . Retrieved 2021/07/08.