4-Chloropyridine-3-carboxamide

Base Information

• Chemical Name: 4-Chloropyridine-3-carboxamide
• CAS No.: 7418-70-4
• Molecular Formula: C6H5ClN2O
• Molecular Weight: 156.5697
• Hs Code.: 2933399090
• Mol file: 7418-70-4.mol

Synonyms:4-Chloronicotinamide;NSC527178;4-Chloro-3-pyridinecarboxamide;Nicotinamide,4-chloro- (7CI);

Chemical Property of 4-Chloropyridine-3-carboxamide

Chemical Property:

• Vapor Pressure: 0.00119mmHg at 25°C
• Refractive Index: 1.588
• Boiling Point: 299.5 °C at 760 mmHg
• Flash Point: 134.9 °C
• PSA: 55.98000
• Density: 1.381 g/cm³
• LogP: 1.53420
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloropyridine-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloropyridine-3-carboxamide

There total 5 articles about 4-Chloropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.6%

4-chloronicotinic acid (10177-29-4) → 4-chloropyridine-3-carboxyamide (7418-70-4)

Guidance literature:

4-chloronicotinic acid; With thionyl chloride; for 4h; Heating / reflux;

With ammonia; In water; at 0 ℃;

Reference yield:

3-carboxy-4-chloropyridine hydrochloride (100191-53-5) → 4-chloropyridine-3-carboxyamide (7418-70-4)

Guidance literature:

3-carboxy-4-chloropyridine hydrochloride; With thionyl chloride; N,N-dimethyl-formamide; for 12h; Heating / reflux;

With ammonium chloride; triethylamine; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

4-chloro-nicotinonitrile (89284-61-7) → 4-chloropyridine-3-carboxyamide (7418-70-4)

Guidance literature:

With 5% Pd/CeO2; In water; at 140 ℃; for 18h;

upstream raw materials:

nicotinamide

3-carboxy-4-chloropyridine hydrochloride

4-chloronicotinic acid

4-chloro-nicotinonitrile

Downstream raw materials:

2-phenyl-4H-pyrido[3,4-e][1,3]oxazin-4-one

4-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-5-hydroxypyrimidin-4-yl}amino)pyridine-3-carboxamide

Refernces

• 1、 -. "Raf inhibitor compounds and methods of use thereof". Page/Page column 47. . Retrieved 2010/11/26.
• 2、 Belen'kii, Leonid I.,Poddubnyi, Igor S.,Krayushkin, Mikhail M.. "A new redox system: Trichloromethylarene - Pyridine base. On the mechanism of the synthesis of N-(4-pyridyl)pyridinium dichloride". . p. 5075 - 5078. Retrieved 2007/10/02.