5-ACETYL-2-AMINO-4-METHYLPYRIMIDINE

Base Information

• Chemical Name: 5-ACETYL-2-AMINO-4-METHYLPYRIMIDINE
• CAS No.: 66373-25-9
• Molecular Formula: C7H9N3O
• Molecular Weight: 151.168
• Hs Code.: 2933599090
• Mol file: 66373-25-9.mol

Synonyms:5-Acetyl-2-amino-4-methylpyrimidine,97%;Ethanone, 1-(2-amino-4-methyl-5-pyrimidinyl)- (9CI);1-(2-Amino-4-methylpyrimidin-5-yl)ethan-1-one;5-Acetyl-2-amino-4-methylpyrimidine 99%;

Chemical Property of 5-ACETYL-2-AMINO-4-METHYLPYRIMIDINE

Chemical Property:

• Vapor Pressure: 2.98E-05mmHg at 25°C
• Melting Point: 226-227°C
• Refractive Index: 1.573
• Boiling Point: 356.2 °C at 760 mmHg
• PKA: 2.25±0.10(Predicted)
• Flash Point: 169.2 °C
• PSA: 68.87000
• Density: 1.2 g/cm³
• LogP: 1.15100

Purity/Quality:

99% ^*data from raw suppliers

5-Acetyl-2-amino-4-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-ACETYL-2-AMINO-4-METHYLPYRIMIDINE

There total 3 articles about 5-ACETYL-2-AMINO-4-METHYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-dimethylaminomethylenepentane-2,4-dione (18856-72-9) + guanidine acetic acid (593-87-3) → acetyl-5 amino-2 methyl-4 pyrimidine (66373-25-9)

Guidance literature:

With sodium ethanolate; In ethanol; for 1h; Heating;

DOI:10.1002/jhet.5570200328

Reference yield:

ethoxylideneacetylacetone (33884-41-2) + guanidine hydrochloride (50-01-1) → acetyl-5 amino-2 methyl-4 pyrimidine (66373-25-9)

Guidance literature:

With ethanol; sodium ethanolate;

DOI:10.1021/ja01224a024

Reference yield:

→ acetyl-5 amino-2 methyl-4 pyrimidine (66373-25-9)

Guidance literature:

/BRN= 506044/ (1b), Ethoxymethylenacetylaceton (2), NaOC2H5;

upstream raw materials:

ethoxylideneacetylacetone

guanidine hydrochloride

3-dimethylaminomethylenepentane-2,4-dione

guanidine acetic acid

Downstream raw materials:

N₂-(4-fluorophenyl)-4'-methyl-4,5'-bipyrimidinyl-2,2'-diamine

C₂₄H₂₀N₄O₂

phenylhydrazone de l'acetyl-4 methyl-3 phenyl-1 pyrazole

acetyl-4 methyl-3 phenyl-1 pyrazole

Refernces