2,4,5-TRIBROMOPHENOL

Base Information

• Chemical Name: 2,4,5-TRIBROMOPHENOL
• CAS No.: 14401-61-7
• Molecular Formula: C6H3Br3O
• Molecular Weight: 330.801
• Mol file: 14401-61-7.mol

Synonyms:2,4,5-Tribromophenol;

Chemical Property of 2,4,5-TRIBROMOPHENOL

Chemical Property:

• Vapor Pressure: 0.000876mmHg at 25°C
• Refractive Index: 1.674
• Boiling Point: 295.3 °C at 760 mmHg
• Flash Point: 132.4 °C
• PSA: 20.23000
• Density: 2.424 g/cm³
• LogP: 3.67970

Purity/Quality:

99%, ^*data from raw suppliers

2,4,5-Tribromophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4,5-Tribromophenol is a standard for environmental testing and research. Determination of urinary bromophenols (BrPs) as potential biomarkers for human exposure to polybrominated di-Ph ethers (PBDEs) using gas chromatography-tandem mass spectrometry (GC-MS/MS). Study of the inhibitory potency of BDE-47 and BDE-99 towards CYP2B6-mediated metabolism of bupropion in human liver microsomes.

Technology Process of 2,4,5-TRIBROMOPHENOL

There total 21 articles about 2,4,5-TRIBROMOPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

2,4,5-tribromophenyl acetate (855429-70-8) → 2,4,5-tribromophenol (14401-61-7)

Guidance literature:

With potassium hydroxide; In methanol; for 24h; Heating;

DOI:10.1016/j.tet.2006.01.092

Reference yield: 78.0%

2,4,5-tribromoaniline (615-86-1) → 2,4,5-tribromophenol (14401-61-7)

Guidance literature:

2,4,5-tribromoaniline; With trifluoroacetic acid; sodium nitrite; at 0 ℃;

With sulfuric acid; sodium sulfate; for 0.833333h; Heating;

DOI:10.1021/es0107475

Reference yield:

2,3,5-tribromo-6-hydroxy-benzoic acid (57688-20-7) → 2,4,5-tribromophenol (14401-61-7)

Guidance literature:

With soda lime; at 200 ℃;

DOI:10.1021/ja01862a072

upstream raw materials:

1,2,4,5-tetrabromobenzene

3-Bromophenol

Pentabromophenol

2,4,5-tribromoaniline

Downstream raw materials:

2,3,4,6-tetrabromophenol

2,2',4,4',5,5'-hexabromobiphenyl ether

3,4,6-tribromo-2-nitro-anisole

3,4,6-tribromo-2-nitro-phenol

Refernces

• 1、 Ruzo et al.. "". . p. 291. Retrieved 1976.
• 2、 Hovander,Malmberg,Athanasiadou,Athanassiadis,Rahm,Bergman,Wehler, E. Klasson. "Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma". . p. 105 - 117. Retrieved 2007/10/03.
• 3、 -. "Process for producing polyhalogenated phenols". . . Retrieved 2008/06/13.