Biguanide hydrochloride

Base Information

• Chemical Name: Biguanide hydrochloride
• CAS No.: 4761-93-7
• Molecular Formula: C2H8ClN5
• Molecular Weight: 137.572
• Mol file: 4761-93-7.mol

Synonyms:Biguanide,monohydrochloride (8CI);Imidodicarbonimidic diamide, monohydrochloride (9CI);Guanylguanidinium chloride;

Chemical Property of Biguanide hydrochloride

Chemical Property:

• Appearance/Colour: white to off-white crystalline powder
• Boiling Point: 267.2 °C at 760 mmHg
• Flash Point: 115.4 °C
• PSA: 111.77000
• LogP: 1.15590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Aqueous Acid (Slightly), DMSO (Soluble, Heated, Sonicated), Methanol (Slightly,

Purity/Quality:

97 % ^*data from raw suppliers

Biguanidehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Biguanides are a class of oral antidiabetic drugs for type 2 diabetes, reducing hepatic glucose production, often used in combination therapy with secretagogues.

Technology Process of Biguanide hydrochloride

There total 3 articles about Biguanide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

guanidine hydrochloride (50-01-1) → imidodicarbonimidic diamide hydrochloride (4761-93-7)

Guidance literature:

With potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; at 115 ℃; Reagent/catalyst;

DOI:10.1021/acs.oprd.0c00246

Reference yield:

dicyandiamide (127099-85-8,780722-26-1) + ammonium chloride → imidodicarbonimidic diamide hydrochloride (4761-93-7)

Guidance literature:

In melt; 160°C;

Reference yield:

→ imidodicarbonimidic diamide hydrochloride (4761-93-7)

Guidance literature:

upstream raw materials:

dicyandiamide

guanidine hydrochloride

Downstream raw materials:

BIGUANIDE

6-(perfluoropropyl)-1,3,5-triazine-2,4-diamine

5-(2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine

benzoguanamine

Refernces

• 1、 Basu, Kallol,Lehnherr, Dan,Martin, Gary E.,Desmond, Richard A.,Lam, Yu-Hong,Peng, Feng,Chung, John Y.L.,Arvary, Rebecca A.,Zompa, Michael A.,Zhang, Si-Wei,Liu, Jinchu,Dance, Zachary E.X.,Larpent, Patrick,Cohen, Ryan D.,Guzman, Francisco J.,Rogus, Nicholas J.,Di Maso, Michael J.,Ren, Hong,Maloney, Kevin M.. "Development of a green and sustainable manufacturing process for gefapixant citrate (MK-7264) Part 3: Development of a one-pot formylation-cyclization sequence to the diaminopyrimidine core". . p. 2462 - 2477. Retrieved 2020.
• 2、 -. "Method of making 1-(alkoxyphenyl)-5-(phenyl)biguanide compounds which are useful as agricultural fungicides". . . Retrieved 2008/06/13.