7-Methyl-6-methylthio-7H-purine

Base Information

• Chemical Name: 7-Methyl-6-methylthio-7H-purine
• CAS No.: 1008-01-1
• Molecular Formula: C7H8 N4 S
• Molecular Weight: 180.233
• Hs Code.: 2933990090
• Mol file: 1008-01-1.mol

Synonyms:Purine,7-methyl-6-(methylthio)- (7CI,8CI); 7-Methyl-6-methylmercaptopurine; NSC 19648

Chemical Property of 7-Methyl-6-methylthio-7H-purine

Chemical Property:

• Vapor Pressure: 2.19E-05mmHg at 25°C
• Boiling Point: 360.7°C at 760 mmHg
• Flash Point: 171.9°C
• PSA: 68.90000
• Density: 1.43g/cm³
• LogP: 1.08520

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Methyl-6-methylthio-7H-purine

There total 7 articles about 7-Methyl-6-methylthio-7H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

6-methylthiopurine (50-66-8) + methyl iodide (74-88-4) → 7-methyl-6-(methylthio)-7H-purine (1008-01-1) + 9-methyl-6-methylthiopurine (1127-75-9)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In water; acetonitrile; at 50 ℃; for 0.5h; Microwave irradiation; Sealed tube;

DOI:10.1002/jhet.4407

Reference yield: 80.0%

6-methylthiopurine (50-66-8) + methyl iodide (74-88-4) → 7-methyl-6-(methylthio)-7H-purine (1008-01-1)

Guidance literature:

6-methylthiopurine; With methylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 70 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02994

Reference yield: 58.0%

6-chloro-7-methyl-7H-purine (5440-17-5) + carbonic acid dimethyl ester (616-38-6) → 7-methyl-6-(methylthio)-7H-purine (1008-01-1)

Guidance literature:

With potassium tert-butylate; palladium diacetate; triphenylphosphine; potassium thioacetate; In dimethyl sulfoxide; at 120 ℃; Inert atmosphere;

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

6-Mercaptopurine

methyl iodide

6-methylthiopurine

Downstream raw materials:

methylthiol

Refernces

• 1、 Wang, Ming,Qiao, Zongjun,Zhao, Jiaoyan,Jiang, Xuefeng. "Palladium-Catalyzed Thiomethylation via a Three-Component Cross-Coupling Strategy". supporting information. p. 6193 - 6197. Retrieved 2018/09/25.
• 2、 Chen, Shuai,Graceffa, Russell F.,Boezio, Alessandro A.. "Direct, Regioselective N-Alkylation of 1,3-Azoles". supporting information. p. 16 - 19. Retrieved 2016/01/15.