Glycinamide ribonucleotide

Base Information

• Chemical Name: Glycinamide ribonucleotide
• CAS No.: 10074-18-7
• Molecular Formula: C7H15 N2 O8 P
• Molecular Weight: 286.178
• UNII: K343GZ6PUY
• DSSTox Substance ID: DTXSID70143478
• Nikkaji Number: J372.863C
• Wikipedia: Glycineamide_ribonucleotide
• Wikidata: Q3109339
• Metabolomics Workbench ID: 37978
• Mol file: 10074-18-7.mol

Synonyms:5'-phosphoribosylglycineamide;glycineamide ribonucleotide;glycineamideribotide

Chemical Property of Glycinamide ribonucleotide

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 1.86±0.10(Predicted)
• Flash Point: °C
• PSA: 181.38000
• Density: 1.72g/cm³
• LogP: -2.29150
• XLogP3: -6.8
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 5
• Exact Mass: 286.05660244
• Heavy Atom Count: 18
• Complexity: 346

Purity/Quality:

98%,99%, ^*data from raw suppliers

Glycinamide ribonucleotide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1C(C(C(O1)NC(=O)CN)O)O)OP(=O)(O)O
• Isomeric SMILES: C([C@@H]1[C@H]([C@H]([C@@H](O1)NC(=O)CN)O)O)OP(=O)(O)O
• Uses: Glycinamide Ribonucleotide is a matte releasing agent.

Technology Process of Glycinamide ribonucleotide

There total 2 articles about Glycinamide ribonucleotide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-ribose 5-phosphate (34980-66-0) + glycine (56-40-6,18875-39-3,25718-94-9) → β-glycinamide ribonucleotide (10074-18-7)

Guidance literature:

With ammonium hydroxide; ATP; magnesium chloride; In aq. phosphate buffer; at 37 ℃; for 4h; pH=7.4; Enzymatic reaction;

DOI:10.1371/journal.pone.0208947

Reference yield:

→ β-glycinamide ribonucleotide (10074-18-7)

Guidance literature:

Acetonid 7, 1.) HCl, Glykol, 2.) H2, Pd/C;

DOI:10.1016/S0008-6215(00)84238-X

upstream raw materials:

D-ribose 5-phosphate

glycine

Refernces

• 1、 Mádrová, Lucie,Krijt, Matyá?,Bare?ová, Veronika,Václavík, Jan,Friedecky, David,Dobe?ová, Dana,Sou?ková, Olga,?kopová, Václava,Adam, Tomá?,Zikánová, Marie. "Mass spectrometric analysis of purine de novo biosynthesis intermediates". . . Retrieved 2019/01/03.