Corticosterone acetate

Base Information

• Chemical Name: Corticosterone acetate
• CAS No.: 1173-26-8
• Molecular Formula: C23H32 O5
• Molecular Weight: 388.504
• European Community (EC) Number: 214-635-8
• NSC Number: 81764
• UNII: KN17U0V6BL
• DSSTox Substance ID: DTXSID301020284
• Nikkaji Number: J15.036C
• Wikidata: Q27115843
• Mol file: 1173-26-8.mol

Synonyms:corticosterone acetate

Chemical Property of Corticosterone acetate

Chemical Property:

• Vapor Pressure: 5.14E-14mmHg at 25°C
• Melting Point: 151oC
• Refractive Index: 1.6120 (estimate)
• Boiling Point: 542.2°C at 760 mmHg
• PKA: 14.48±0.70(Predicted)
• Flash Point: 183.5°C
• PSA: 80.67000
• Density: 1.2g/cm³
• LogP: 3.23750
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Acetone (Slightly), Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (S
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 388.22497412
• Heavy Atom Count: 28
• Complexity: 739

Purity/Quality:

98%,99%, ^*data from raw suppliers

Corticosterone 21-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OCC(=O)C1CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C
• Isomeric SMILES: CC(=O)OCC(=O)[C@H]1CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C
• Uses: Corticosterone (C695700) derivative. An intermediate in the biosynthesis of aldosterone, isolated from the adrenal cortex.

Technology Process of Corticosterone acetate

There total 14 articles about Corticosterone acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Corticosterone (50-22-6) + acetic anhydride (108-24-7) → corticosterone-21-acetate (1173-26-8)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.1016/0039-128X(93)90009-C

Reference yield:

HYDROCORTISONE (50-23-7) → corticosterone-21-acetate (1173-26-8)

Guidance literature:

With acetic acid; zinc; Behandeln des Reaktionsprodukts mit Acetanhydrid unr Pyridin;

DOI:10.1039/jr9560000517

Reference yield:

21-acetoxy-11β-hydroxy-5β-pregnane-3,20-dione (115073-83-1) → corticosterone-21-acetate (1173-26-8)

Guidance literature:

With bromine; acetic acid; Erhitzen des Reaktionsprodukts mit Pyridin;

DOI:10.1002/hlca.194402701164

upstream raw materials:

Ketene

Corticosterone

HYDROCORTISONE

21-acetoxy-11β-hydroxy-5β-pregnane-3,20-dione

Downstream raw materials:

Corticosterone

21-acetoxy-pregna-4,9(11)-diene-3,20-dione

21-acetoxy-pregn-4-ene-3,11,20-trione

20β_F-acetoxy-11β,21-dihydroxy-pregn-4-en-3-one

Refernces

• 1、 Norymberski. "-". . p. 517. Retrieved 1956.
• 2、 Salce et al.. "". . p. 1681. Retrieved 1970.
• 3、 Bao, Yuanwu,Li, Chuan,Shen, Heongwu,Nan, Fajun. "Determination of saikosaponin derivatives in Radix bupleuri and in pharmaceuticals of the Chinese multiherb remedy Xiaochaihu-tang using liquid chromatographic tandem mass spectrometry". . p. 4208 - 4216. Retrieved 2007/10/03.