2-(1H-pyrazol-5-yl)acetic acid

Base Information

• Chemical Name: 2-(1H-pyrazol-5-yl)acetic acid
• CAS No.: 102732-63-8
• Molecular Formula: C5H6N2O2
• Molecular Weight: 126.11300
• Hs Code.: 2933199090
• Mol file: 102732-63-8.mol

Synonyms:pyrazolyl-3-acetic acid;2-(1H-pyrazol-3-yl)acetic acid;(1(2)H-pyrazol-3-yl)-acetic acid;pyrazol-3-ylacetic acid;1H-Pyrazole-3-acetic acid;(1(2)H-Pyrazol-3-yl)-essigsaeure;

Chemical Property of 2-(1H-pyrazol-5-yl)acetic acid

Chemical Property:

• Boiling Point: 387.3±17.0 °C(Predicted)
• PKA: 4.06±0.10(Predicted)
• PSA: 65.98000
• Density: 1.426±0.06 g/cm3(Predicted)
• LogP: 0.03680
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

2-(1H-Pyrazol-5-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(1H-Pyrazol-5-yl)acetic Acid is used in preparation of inhibitors of cGAS.

Technology Process of 2-(1H-pyrazol-5-yl)acetic acid

There total 6 articles about 2-(1H-pyrazol-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1H-pyrazol-3-yl)acetic acid methyl ester (878678-79-6) → 2-(1H-pyrazol-3-yl)acetic acid (102732-63-8)

Guidance literature:

With methanol; sodium hydroxide;

Reference yield: 89.0%

2-(1H-pyrazol-3-yl)acetohydrazide (144677-14-5) → 2-(1H-pyrazol-3-yl)acetic acid (102732-63-8)

Guidance literature:

With hydrogenchloride; water; at 100 ℃; for 3h;

Reference yield:

2-(1H-pyrazol-3-yl)acetonitrile (135237-01-3) → 2-(1H-pyrazol-3-yl)acetic acid (102732-63-8)

Guidance literature:

With sodium hydroxide; water;

DOI:10.1021/ja01112a050

upstream raw materials:

2-(1H-pyrazol-3-yl)acetonitrile

5-nitro-2-pyridone

2-(1H-pyrazol-3-yl)acetohydrazide

methyl 3-hydroxy-2-thiophenecarboxylate

Downstream raw materials:

2-(1-methyl-1H-pyrazol-5-yl)acetic acid

2-(1-methyl-1H-pyrazol-3-yl)acetic acid

ethyl 2-(1H-pyrazol-3-yl)acetate

Refernces

• 1、 -. "BIARYL COMPOUND, PREPARATION METHOD AND USE THEREFOR". Paragraph 0074; 0076. . Retrieved 2020/01/02.
• 2、 -. "TYK2 INHIBITORS AND USES THEREOF". Paragraph 00252. . Retrieved 2017/03/21.