4-(2-Aminoethyl)benzenesulfonyl fluoride;hydron;chloride

Base Information

• Chemical Name: 4-(2-Aminoethyl)benzenesulfonyl fluoride;hydron;chloride
• CAS No.: 30827-99-7
• Molecular Formula: C8H10FNO2S^.HCl
• Molecular Weight: 239.698
• Hs Code.: 29214990
• Mol file: 30827-99-7.mol

Synonyms:

Chemical Property of 4-(2-Aminoethyl)benzenesulfonyl fluoride;hydron;chloride

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 7.72E-05mmHg at 25°C
• Melting Point: 175-177 °C
• Boiling Point: 292.5 °C at 760 mmHg
• Flash Point: 130.7 °C
• PSA: 68.54000
• LogP: 3.42910
• Storage Temp.: 0-6°C
• Sensitive.: Moisture Sensitive
• Solubility.: H2O: soluble50mg/mL (stable for up to six months if stored refri
• Water Solubility.: 10 g/L (20 ºC)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 239.0183056
• Heavy Atom Count: 14
• Complexity: 239

Purity/Quality:

98%,99%, ^*data from raw suppliers

AEBSF Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 45-36/37/39-26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].C1=CC(=CC=C1CCN)S(=O)(=O)F.[Cl-]
• Description: AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.
• Uses: AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation. Recommended concentrations for use are 0.1-1 mM.