Formamide, N-methyl-N-[9-(phenylmethyl)-9H-purin-6-yl]-

Base Information

• Chemical Name: Formamide, N-methyl-N-[9-(phenylmethyl)-9H-purin-6-yl]-
• CAS No.: 112089-02-8
• Molecular Formula: C14H13N5O
• Molecular Weight: 267.29
• Mol file: 112089-02-8.mol

Synonyms:

Chemical Property of Formamide, N-methyl-N-[9-(phenylmethyl)-9H-purin-6-yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Formamide, N-methyl-N-[9-(phenylmethyl)-9H-purin-6-yl]-

There total 4 articles about Formamide, N-methyl-N-[9-(phenylmethyl)-9H-purin-6-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

methyl-(9-benzyl-9H-purin-6-yl)amine (81060-73-3) + formyl acetic anhydride (2258-42-6) → 9-benzyl-6-(N-methylformamido)-9H-purine (112089-02-8)

Guidance literature:

With dmap; In dichloromethane; for 16h; Ambient temperature;

DOI:10.1021/jm00398a019

Reference yield:

9-benzyl-6-chloro-9H-purine (1928-76-3) → 9-benzyl-6-(N-methylformamido)-9H-purine (112089-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / aq. NaOH / ethanol / 15 h / Ambient temperature

2: 58 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

With dmap; sodium hydroxide; In ethanol; dichloromethane;

DOI:10.1021/jm00398a019

Reference yield:

benzyl bromide (100-39-0) → 9-benzyl-6-(N-methylformamido)-9H-purine (112089-02-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / K₂CO₃ / dimethylsulfoxide / 39 h / Ambient temperature

2: 81 percent / aq. NaOH / ethanol / 15 h / Ambient temperature

3: 58 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

With dmap; sodium hydroxide; potassium carbonate; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm00398a019

upstream raw materials:

methyl-(9-benzyl-9H-purin-6-yl)amine

formyl acetic anhydride

9-benzyl-6-chloro-9H-purine

benzyl bromide

Refernces